Another Suspect case of Creutzfeldt-Jakob disease investigated in Brazil

Suspect case of Creutzfeldt-Jakob disease investigated in Brazil

brain disease Brazil Creutzfeldt-Jakob disease Latin America and the Caribbean prion prion disease transmissible spongiform encephalopathies

The death of a 70-year-old man from Belo Horizonte, Brazil is being investigated by health authorities as possibly being caused by the prion disease, Creutzfeldt-Jakob disease (CJD), according to a Wall Street Journal report Tuesday.

According to the report, tissue samples are currently be analyzed to determine if the cause of death was CJD. Last year, health officials in the city investigated four other suspect cases; however, all tested negative for CJD.

Creutzfeldt-Jakob disease (CJD) is a rare and fatal disease that affects the nervous system and causes deterioration of the brain. It affects about one in a million people each year worldwide. In the United States, only about 200 people are diagnosed with CJD each year.

In the early stages of CJD, the patient may have rapidly failing memory and other cognitive difficulties. These symptoms become worse much faster than with other more common types of dementia, such as Alzheimer’s disease. Other symptoms can include personality changes including anxiety and depression, lack of coordination, and visual disturbances. As the illness progresses, mental deterioration becomes pronounced and involuntary movements such as sudden jerky movements, blindness, weakness of extremities, and coma may occur. There is no treatment or cure.


http://www.theglobaldispatch.com/suspect-case-of-creutzfeldt-jakob-disease-investigated-in-brazil-81276/


>>> health officials in the city investigated four other suspect cases; however, all tested negative for CJD. ...

???

makes you wonder who’s doing the testing, and what test are being used ???

tss



Friday, December 07, 2012

ATYPICAL BSE BRAZIL 2010 FINALLY CONFIRMED OIE 2012

http://bse-atypical.blogspot.com/2012/12/atypical-bse-brazil-2010-finally.html


Wednesday, December 19, 2012


Scientific Report of the European Food Safety Authority on the Assessment of the Geographical BSE Risk (GBR) of Brazil

http://bse-atypical.blogspot.com/2012/12/scientific-report-of-european-food.html


Sunday, December 15, 2013

*** FDA PART 589 -- SUBSTANCES PROHIBITED FROM USE IN ANIMAL FOOD OR FEED VIOLATIONS OFFICIAL ACTION INDICATED OAI UPDATE DECEMBER 2013 UPDATE

http://madcowusda.blogspot.com/2013/12/fda-part-589-substances-prohibited-from.html


Wednesday, January 01, 2014

Molecular Barriers to Zoonotic Transmission of Prions

*** chronic wasting disease, there was no absolute barrier to conversion of the human prion protein.

*** Furthermore, the form of human PrPres produced in this in vitro assay when seeded with CWD, resembles that found in the most common human prion disease, namely sCJD of the MM1 subtype.

http://wwwnc.cdc.gov/eid/article/20/1/13-0858_article.htm

http://chronic-wasting-disease.blogspot.com/2014/01/molecular-barriers-to-zoonotic.html


Subtype 1: (sCJDMM1 and sCJDMV1)

This subtype is observed in patients who are MM homozygous or MV heterozygous at codon 129 of the PrP gene (PRNP) and carry PrPSc Type 1. Clinical duration is short, 3‑4 months.32 The most common presentation in sCJDMM1 patients is cognitive impairment leading to frank dementia, gait or limb ataxia, myoclonic jerks and visual signs leading to cortical blindness (Heidenhain’s syndrome)...

https://www.landesbioscience.com/pdf/06Ahmad_Liberski.pdf


Animals injected with iatrogenic Creutzfeldt–Jakob disease MM1 and genetic Creutzfeldt–Jakob disease MM1 linked to the E200K mutation showed the same phenotypic features as those infected with sporadic Creutzfeldt–Jakob disease MM1 prions...

http://brain.oxfordjournals.org/content/early/2010/09/07/brain.awq234.full.pdf

*** our results raise the possibility that CJD cases classified as VV1 may include cases caused by iatrogenic transmission of sCJD-MM1 prions or food-borne infection by type 1 prions from animals, e.g., chronic wasting disease prions in cervid. In fact, two CJD-VV1 patients who hunted deer or consumed venison have been reported (40, 41). The results of the present study emphasize the need for traceback studies and careful re-examination of the biochemical properties of sCJD-VV1 prions. ***

http://www.jbc.org/cgi/content/abstract/M704597200v1?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Cross-sequence+transmission+of+sporadic+Creutzfeldt-Jakob+disease+creates+a+new+&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

snip...see full text ;

http://transmissiblespongiformencephalopathy.blogspot.com/2011/01/agent-strain-variation-in-human-prion.html


Friday, January 17, 2014

Annual report of the Scientific Network on BSE-TSE EFSA, Question No EFSA-Q-2013-01004, approved on 11 December 2013

TECHNICAL REPORT

http://efsaopinionbseanimalprotein.blogspot.com/2014/01/annual-report-of-scientific-network-on.html


Sunday, January 19, 2014

National Prion Disease Pathology Surveillance Center Cases Examined1 as of January 8, 2014

http://prionunitusaupdate.blogspot.com/2014/01/national-prion-disease-pathology.html


Thursday, January 23, 2014

Medical Devices Containing Materials Derived from Animal Sources (Except for In Vitro Diagnostic Devices) [Docket No. FDA–2013–D–1574]

http://transmissiblespongiformencephalopathy.blogspot.com/2014/01/medical-devices-containing-materials.html


Wednesday, January 15, 2014

INFECTION PREVENTION AND CONTROL OF CJD, VCJD AND OTHER HUMAN PRION DISEASES IN HEALTHCARE AND COMMUNITY SETTINGS Variably Protease-Sensitive Prionopathy (VPSPr) January 15, 2014

http://transmissiblespongiformencephalopathy.blogspot.com/2014/01/infection-prevention-and-control-of-cjd.html


Sunday, August 11, 2013

Creutzfeldt-Jakob Disease CJD cases rising North America updated report August 2013

*** Creutzfeldt-Jakob Disease CJD cases rising North America with Canada seeing an extreme increase of 48% between 2008 and 2010

http://creutzfeldt-jakob-disease.blogspot.com/2013/08/creutzfeldt-jakob-disease-cjd-cases.html


Sunday, October 13, 2013

*** CJD TSE Prion Disease Cases in Texas by Year, 2003-2012

http://creutzfeldt-jakob-disease.blogspot.com/2013/10/cjd-tse-prion-disease-cases-in-texas-by.html


Saturday, November 16, 2013

Management of neurosurgical instruments and patients exposed to creutzfeldt-jakob disease 2013 December

Infect Control Hosp Epidemiol.

http://creutzfeldt-jakob-disease.blogspot.com/2013/11/management-of-neurosurgical-instruments.html


Monday, December 02, 2013

*** A parliamentary inquiry has been launched today into the safety of blood, tissue and organ screening following fears that vCJD – the human form of ‘mad cow’ disease – may be being spread by medical procedures

http://creutzfeldt-jakob-disease.blogspot.com/2013/12/a-parliamentary-inquiry-has-been.html


Wednesday, December 11, 2013

Detection of Infectivity in Blood of Persons with Variant and Sporadic Creutzfeldt-Jakob Disease

http://creutzfeldt-jakob-disease.blogspot.com/2013/12/detection-of-infectivity-in-blood-of.html


wasted days and wasted nights...Freddy Fender

MOM DOD 12/14/97 confirm ‘hvCJD’ just made a promise to mom, NEVER FORGET! and never let them forget. ...

kind regards, terry

layperson

Terry S. Singeltary Sr. P.O. Box 42 Bacliff, Texas USA 77518 flounder9@verizon.net


Wednesday, January 29, 2014

Another Suspect case of Creutzfeldt-Jakob disease investigated in Brazil

http://creutzfeldt-jakob-disease.blogspot.com/2014/01/another-suspect-case-of-creutzfeldt.html

National Prion Disease Pathology Surveillance Center Update 1/8/2014

Sunday, January 19, 2014

National Prion Disease Pathology Surveillance Center Cases Examined1 as of January 8, 2014

http://prionunitusaupdate.blogspot.com/2014/01/national-prion-disease-pathology.html


kind regards,
terry

 

 

 

The Anspach Effort, Inc. RECALL FDA Blackmax motor had been used in a case where the patient was diagnosed with Creutzfeldt-Jacob Disease (CJD) MARYLAND HOSTPITAL

Enforcement Report - Week of January 15, 2014

 

Enforcement Reports

 

4 - Product Detail Product Description Anspach BLACKMAX-N (Pneumatic motor) and Autolube III (Foot Control). Cutting and shaping bone.

 

Recall Number Z-0631-2014 Classification Class II Code Info Serial # 1934, 3135, 50229989-3, and 31496704 (BLACKMAX-N) Serial # 80017906 (Foot Control)

 

Product Distributed Qty 4 ( BLACKMAX-N) and 1 (Foot Control)

 

Reason For Recall Anspach was contacted by a hospital to inform Anspach that a Blackmax motor had been used in a case where the patient was diagnosed with Creutzfeldt-Jacob Disease (CJD).

 

Event Detail Event Id 67131

 

Product Type Devices Status

 

Completed Recalling Firm The Anspach Effort, Inc. City Palm Beach Gardens State FL Country US

 

Voluntary / Mandated Voluntary: Firm Initiated Recall Initiation Date 2012-06-11

 

Initial Firm Notification of Consignee or Public Telephone Distribution Pattern

 

US Distribution: Maryland only.

 

 

http://www.accessdata.fda.gov/scripts/enforcement/enforce_rpt-Product-Tabs.cfm?action=select&recall_number=Z-0631-2014&w=01152014&lang=eng

 

 

 

Product Detail

 

Product Description  Anspach B-Blue-S 11.25 cm attachment and Anspach B-Green Standard Craniotome. Cutting and shaping bone. 

 

Recall Number  Z-0632-2014 

 

Classification  Class II 

 

Code Info  Serial # 50152011-14 (B-Blue-S) Serial # 31447408 (B-Green) 

 

Product Distributed Qty  1 B-Blue-S and 1 B-Green 

 

Reason For Recall  Anspach was contacted by a hospital to inform Anspach that a Blackmax motor had been used in a case where the patient was diagnosed with Creutzfeldt-Jacob Disease (CJD). 

 

Event Detail

 

Event Id  67131 

 

Product Type  Devices 

 

Status  Completed 

 

Recalling Firm  The Anspach Effort, Inc. 

 

City  Palm Beach Gardens 

 

State  FL 

 

Country  US 

 

Voluntary / Mandated  Voluntary: Firm Initiated

 

Recall Initiation Date  2012-06-11 

 

Initial Firm Notification of Consignee or Public  Telephone

 

Distribution Pattern  US Distribution: Maryland only. 

 

 

http://www.accessdata.fda.gov/scripts/enforcement/enforce_rpt-Product-Tabs.cfm?action=select&recall_number=Z-0632-2014&w=01152014&lang=eng

 

 

Class 2 Recall

 

Anspach BLACKMAXN (Pneumatic motor) and Autolube III  see related information21

 

Date Posted January 06, 2014

 

Recall Status1 Open

 

Recall Number Z-0631-2014

 

Product Classification Motor, Surgical Instrument, Ac-Powered22 - Product Code GEY23

 

Product Anspach BLACKMAX-N (Pneumatic motor) and Autolube III (Foot Control). Cutting and shaping bone.

 

Code Information Serial # 1934, 3135, 50229989-3, and 31496704 (BLACKMAX-N) Serial # 80017906 (Foot Control)

 

Recalling Firm/

 

Manufacturer The Anspach Effort, Inc.

 

4500 Riverside Drive

 

Palm Beach Gardens, Florida 33410-4235

 

Manufacturer Reason

 

for Recall Anspach was contacted by a hospital to inform Anspach that a Blackmax motor had been used in a case where the patient was diagnosed with Creutzfeldt-Jacob Disease (CJD). 

 

Action none. 

 

Quantity in Commerce 4 ( BLACKMAX-N) and 1 (Foot Control)

 

Distribution Distributed in the state of Maryland.

 

Total Product Life Cycle TPLC Device Report24 

 

 

--------------------------------------------------------------------------------

  

1 For details about termination of a recall see Code of Federal Regulations (CFR) Title 21 §7.5525 

 

 

http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfRes/res.cfm?ID=124751

 

 

 

Synthes Anspach Mechanical Reprocessing Tray (MERET)

 

 

Device Description

 

Tray that facilitates reprocessing of Synthes Anspach devices in a mechanical cleaner.

 

DO NOT reprocess the following Synthes Anspach Devices in a mechanical cleaner.

 

– AutoLube

 

– eMax® System Consoles and Foot Controls

 

– iMRI Foot Control

 

– Powered Irrigation Pump

 

Indications For Use

 

Intended to securely hold the Synthes Anspach devices listed in Table 1 and Table 2 below while being reprocessed in a hospital’s mechanical cleaner.

 

Contraindications

 

– Do not use to reprocess any devices not listed in Table 1 and Table 2.

 

– Do not use to reprocess dissection tools. Dissection tools are disposable and SINGLE USE ONLY.

 

– Do not use in sterilization procedures.

 

 

snip...

 

Transmissible Spongiform Encephalopathies (TSE).

 

Anspach will not authorize or accept the return of products that directly contact patients or are contaminated with a patient’s body fluids who is suspected or confirmed with a Transmissible Spongiform Encephalopathies/ Creutzfeldt-Jakob Disease (TSE/CJD) diagnosis. Anspach recommends that all Anspach products used on a patient confirmed with a TSE/CJD diagnosis be incinerated. Anspach dissecting tools used on a patient suspected of TSE/CJD diagnosis must be incinerated. Contact your Sales Representative for replacement of product incinerated under this policy or for temporary equipment while original equipment is quarantined. Contact the Anspach Customer Service Department regarding TSE/CJD contamination for additional information. United States Federal law restricts this device to sale by or on order of a physician or other licensed healthcare provider.

 

 

 

http://www.synthes.com/sites/intl/IntlContent/Files/036.001.499.pdf

 

 

 

Greetings prion world,

 

looks like NO ACTION TAKEN?

 

I wonder which hospital in Maryland this is, where this CJD incident took place ???

 

I wonder if there were any exposures to humans from this incident ???

 

if so, were the patients notified at this hospital ???

 

if not, why not ???

 

 

kind regards,

terry

 

 

 

 

Wednesday, January 15, 2014

 

INFECTION PREVENTION AND CONTROL OF CJD, VCJD AND OTHER HUMAN PRION DISEASES IN HEALTHCARE AND COMMUNITY SETTINGS Variably Protease-Sensitive Prionopathy (VPSPr) January 15, 2014

 

http://transmissiblespongiformencephalopathy.blogspot.com/2014/01/infection-prevention-and-control-of-cjd.html

 

 

 

Wednesday, December 11, 2013

 

*** Detection of Infectivity in Blood of Persons with Variant and Sporadic Creutzfeldt-Jakob Disease

 

http://www.cdc.gov/media/eid/2014/1.html

 

http://creutzfeldt-jakob-disease.blogspot.com/2013/12/detection-of-infectivity-in-blood-of.html

 

 

 

Monday, January 13, 2014

 

*** Prions in Variably Protease-Sensitive Prionopathy: An Update Pathogens 2013 Pathogens 2013, 2, 457-471; doi:10.3390/pathogens2030457

 

http://prionopathy.blogspot.com/2014/01/prions-in-variably-protease-sensitive.html

 

 

 

Friday, January 10, 2014

 

*** vpspr, sgss, sffi, TSE, an iatrogenic by-product of gss, ffi, familial type prion disease, what it ???

 

http://transmissiblespongiformencephalopathy.blogspot.com/2014/01/vpspr-sgss-sffi-tse-iatrogenic-by.html

 

 

 

*** PRICE OF CWD TSE PRION POKER GOES UP 2014 ***

 

 

Wednesday, January 01, 2014

 

Molecular Barriers to Zoonotic Transmission of Prions

 

*** chronic wasting disease, there was no absolute barrier to conversion of the human prion protein.

 

*** Furthermore, the form of human PrPres produced in this in vitro assay when seeded with CWD, resembles that found in the most common human prion disease, namely sCJD of the MM1 subtype.

 

http://wwwnc.cdc.gov/eid/article/20/1/13-0858_article.htm

 

http://chronic-wasting-disease.blogspot.com/2014/01/molecular-barriers-to-zoonotic.html

 

 

 

Saturday, November 16, 2013

 

Management of neurosurgical instruments and patients exposed to creutzfeldt-jakob disease 2013 December

 

Infect Control Hosp Epidemiol.

 

http://creutzfeldt-jakob-disease.blogspot.com/2013/11/management-of-neurosurgical-instruments.html

 

 

 

Thursday, November 14, 2013

 

Prion diseases in humans: Oral and dental implications

 

http://transmissiblespongiformencephalopathy.blogspot.com/2013/11/prion-diseases-in-humans-oral-and.html

 

 

 

Saturday, November 2, 2013

 

Recommendation of the Swiss Expert Committee for Biosafety on the classification of activities using prion genes and prion protein January 2013

 

http://transmissiblespongiformencephalopathy.blogspot.com/2013/11/recommendation-of-swiss-expert.html

 

 

 

 

kind regards,

terry