Canada, New Brunswick, cases of an undiagnosed neurological illness cases, update

I thought I should give an update on Canada, New Brunswick, cases of an undiagnosed neurological illness cases, that so far, has ruled out any prion disease such as Creutzfeldt-Jakob disease (CJD), per Michael Coulthart, who is the head of the Canadian Creutzfeldt-Jakob Disease Surveillance System. …terry

Canada, New Brunswick, cases of an undiagnosed neurological illness cases, update

Health

Data analysis underway in investigation of undiagnosed neurological illness

27 March 2025

FREDERICTON (GNB) – The Office of the Chief Medical Officer of Health has begun the next phase of its investigation into cases of an undiagnosed neurological illness in the province.

The office has received enough complete and verified patient data to work with the Public Health Agency of Canada to conduct an analysis.

“We know New Brunswickers are concerned about this file, and we are, too,” said Dr. Yves Léger, the chief medical officer of health. “We want to get answers for these patients. The results of this analysis and scientific investigation will help us to determine what next steps are needed.”

The investigation started in 2021, when Public Health studied a group of 48 patients with a range of neurological symptoms. The investigation found no evidence of a common illness, and a report was issued on Feb. 24, 2022.

In early 2023, the referring neurologist raised new concerns to Public Health, including more patients reporting unusual symptoms. Since then, the Office of the Chief Medical Officer of Health and the Vitalité Health Network have been working together, with support from the Public Health Agency of Canada, to assist the neurologist in collecting and verifying the patient information needed to allow for further investigation.

The main purpose of this investigation is to further understand concerns brought forward by the physician regarding certain environmental factors.

“There’s been a lot of interest and concern on this topic,” said Léger. “If you want to know more about the objectives, next steps and timelines related to this work, I encourage you to visit our new website dedicated to this topic. We’ll be updating this site regularly as we complete this work.”

Next steps in the investigation include completing the data analysis, interpreting the analysis, a scientific review of the findings, which will be completed by the Public Health Agency of Canada, and finalizing and sharing a report on the work completed and recommended next steps.

The investigation is expected to be completed by summer.

27-03-25

https://www2.gnb.ca/content/gnb/en/news/news_release.2025.03.0115.html

Investigation of cases of undiagnosed neurological illness

The Office of the Chief Medical Officer of Health (OCMOH) is continuing to investigate cases of undiagnosed neurological illness.

Overview

Since becoming aware of cases of a potentially undiagnosed neurological illness, the Government of New Brunswick has led two separate investigations into this matter. Supports have also been provided to affected patients as well as physicians who are caring for these individuals.

The investigation started in 2021, when the Chief Medical Officer of Health studied a group of 48 patients with a range of neurological symptoms. The investigation found no evidence of a common illness among these patients and a report was issued on Feb. 24, 2022. The report included recommendations and follow up actions to support patient care.

The full timeline of the 2021-2022 investigation can be found here.

In early 2023, the referring neurologist raised new concerns, including reporting more patients with unusual symptoms. The physician has suggested different ideas about causes for these symptoms. 

Since then, the Office of the Chief Medical Officer of Health, Vitalité Health Network, and the Public Health Agency of Canada have been working together to support the neurologist in the collection and verification of the required patient information. Once these reports are complete and received, the Chief Medical Officer of Health will analyze the information, interpret the results and make recommendations on any next steps required.

Objectives of Investigation

The purpose of this investigation is to assess concerns of elevated levels of certain environmental substances, and to review relevant files to determine whether a diagnosis has been made for some patients. 

This investigation will not involve establishing criteria to determine the presence of a cluster and its characteristics or detailed clinical review of patient records.

The findings of the current investigation will help determine next steps.

Current status

Current status (updated: March 13, 2025): Analysis underway

As of February 28, 2025, 222 enhanced surveillance forms have been signed off by the referring neurologist. We now have enough fully reported and verified patient data to begin the analysis, with assistance from the Public Health Agency of Canada.

Next steps

What we’ll do    How we’ll do it    When we’ll do it

Data analysis    The data will be analyzed with support from the Public Health Agency of Canada.    Underway

Interpretation of analysis    Office of the Chief Medical Officer of Health to review field epidemiology report of the data analysis, interpret, and make recommendations for next steps.    May-June 2025

Scientific review    Results of the analysis will be sent to the Public Health Agency of Canada for review.    May 2025

Finalize report    Review feedback/comments from the Public Health Agency of Canada. Complete edits and finalize design.    Late Spring 2025

Release report    Share findings and any next steps with the public, affected patients and First Nations.    Late summer 2025

* Timelines are estimates and subject to change. Delays for one activity could impact other steps. Timelines will be updated as required.

Timeline

For the full timeline of the 2021-2022 investigation, click here.

2025

March 2025: Data analysis underway with assistance from Public Health Agency of Canada. All 222 enhanced surveillance forms signed off by referring neurologist included in the analysis. January, 2025: Steps put in place to ensure the neurologist has sufficient time to sign off on the remaining patient files.

2024

December 16, 2024: Office of the Chief Medical Officer of Health mobilized a field epidemiologist from PHAC to assist with creating a detailed data analysis plan for the next phase of this investigation. The field epidemiologist also assisted with creating a draft report template to be populated following completion of the analysis.

July 17, 2024: In-person meeting held with referring neurologist, Office of the Chief Medical Officer of Health and Vitalité Health Network where plan is agreed upon to support the sign-off of patient files received in May, including a reduction in clinic duties and additional support staff.

May 2, 2024: A package with all the of the completed enhanced surveillance forms was provided to the neurologist for review and sign off.

March 18 - April 5, 2024: A Public Health Agency of Canada field epidemiologist and a Vitalité Public Health nurse were mobilized to the referring neurologists office to complete the extraction of data to complete the enhanced surveillance documents.

2023

November 27 - December 20, 2023: Public Health Agency of Canada epidemiologist supporting Public Health and Vitalite Public Health Nurse mobilized to the referring neurologist’s office to assist with data collection efforts. Public Health Agency of Canada Epidemiology helped Public Health develop a database and guidance for data extraction and database entry.

November 9, 2023: Public Health requested assistance from the Public Health Agency of Canada Field Epidemiology program to assist with the data collection step.

July 2023 - September 2023: Public Health requested assistance from Public Health Agency of Canada to help with the completion of a scoping exercise. The purpose of this exercise was to determine the volume, format and type of information collected and available on the patients, in order to help guide data collection. During this time, Public Health Agency of Canada and Public Health worked together to clarify the assistance needed and determine which resources would be most helpful.

April - May 2023: A two-page enhanced surveillance form is developed by the Office of the Chief Medical Officer of Health Epidemiology and Surveillance team to gather necessary data. The form is sent to the referring neurologist.

January 2023: The Chief Medical Officer of Health was notified by the neurologist of his concerns regarding potential environmental exposures to certain substances. They also indicated the number of cases has grown to 147.

2022

February 2022: GNB releases report and concludes investigation into 48 cases.

February 2022: Oversight committee release its findings on 48 cases.

Frequently Asked Questions

Why is government investigating cases of undiagnosed neurological illness?

What’s the difference between this investigation and the investigation in 2021-22?

Who is helping the Government of New Brunswick with this investigation?

What is the role of the Public Health Agency of Canada in this investigation?

Why is it taking so long for the investigation to be completed?

How many patients are involved?

What about the remaining files? Are you capping the number of cases to be included in this investigation?

How can New Brunswickers stay engaged and informed about this process?

How will government help these patients?

https://www2.gnb.ca/content/gnb/en/departments/health/neuro-cluster/investigation.html

Investigation into a Neurological Syndrome of Unknown Cause: An Epidemiological Summary of Enhanced Surveillance Interviews

Epidemiology and Surveillance Branch Public Health New Brunswick

Date: October 26 th , 2021

https://www2.gnb.ca/content/dam/gnb/Departments/h-s/pdf/en/CDC/investigation-neurological-syndrome-unknown-cause.pdf

See archived link;

http://web.archive.org/web/20220124011738/https://www2.gnb.ca/content/dam/gnb/Departments/h-s/pdf/en/CDC/investigation-neurological-syndrome-unknown-cause.pdf

New Brunswick Cluster of Neurological Syndrome of Unknown Cause

https://www2.gnb.ca/content/gnb/en/departments/ocmoh/cdc/neuro_cluster.html

See archived link;

http://web.archive.org/web/20210529052221/https://www2.gnb.ca/content/gnb/en/departments/ocmoh/cdc/neuro_cluster.html

Investigation into a Neurological Syndrome of Unknown Cause: An Epidemiological Summary of Enhanced Surveillance Interviews

Epidemiology and Surveillance Branch Public Health New Brunswick

Date: October 26 th , 2021

https://www2.gnb.ca/content/dam/gnb/Departments/h-s/pdf/en/CDC/investigation-neurological-syndrome-unknown-cause.pdf

See archived link;

http://web.archive.org/web/20211109235939/https://www2.gnb.ca/content/dam/gnb/Departments/h-s/pdf/en/CDC/investigation-neurological-syndrome-unknown-cause.pdf

New Brunswick Cluster of Neurological Syndrome of Unknown Cause

https://www2.gnb.ca/content/gnb/en/departments/ocmoh/cdc/neuro_cluster.html

See archived link;

http://web.archive.org/web/20210603211914/https://www2.gnb.ca/content/gnb/en/departments/ocmoh/cdc/neuro_cluster.html

Michael Coulthart is the head of the Canadian Creutzfeldt-Jakob Disease Surveillance System. He said he’s ruling out a prion disease such as Creutzfeldt-Jakob disease (CJD), but notes that many neurological disorders have features that overlap.

“What we can say with confidence is if we assume that the cluster has a single cause, that cause is not prion disease,” he said in an interview earlier this week. “It has been ruled out in enough people that we are no longer considering this to be a top candidate.”

Researcher says brain disorder in N.B. may be linked to environmental exposure By Kevin Bissett

https://www.niagarafallsreview.ca/ts/news/canada/2021/03/26/researcher-says-brain-disorder-in-nb-may-be-linked-to-environmental-exposure.html?li_source=LI&li_medium=niagarafallsreview_canada

FRIDAY, SEPTEMBER 23, 2022

Neuropathology of 8 patients of the New Brunswick cluster of Neurological Syndrome of Unknown Cause

No prion disease was found in any of the 8 autopsy cases.

https://creutzfeldt-jakob-disease.blogspot.com/2022/09/neuropathology-of-8-patients-of-new.html

WEDNESDAY, OCTOBER 27, 2021

New Brunswick October 27, 2021 - Health minister availability Report on cluster of unknown neurological disorders update

https://cjdusa.blogspot.com/2021/10/new-brunswick-october-27-2021-health.html

THURSDAY, MARCH 18, 2021 

New Brunswick monitoring more than 40 cases of unknown neurological disease symptoms are similar to Creutzfeldt-Jakob disease? 

https://creutzfeldt-jakob-disease.blogspot.com/2021/03/new-brunswick-monitoring-more-than-40.html

terry

Neuropsychiatric symptoms in sporadic Creutzfeldt-Jakob disease

 Neuropsychiatric symptoms in sporadic Creutzfeldt-Jakob disease

Jennifer Zitser, Sven Forner, Katherine Wong, Jin Chengshi, John Neuhaus, Jennifer Martindale, Ben J Raudabaugh, Kendra Benisano, Kelly Goodman-O’Leary, Stacy Metcalf ...

Brain, awaf077, https://doi.org/10.1093/brain/awaf077 Published: 28 March 2025 Article history

Abstract

Although neuropsychiatric symptoms are not part of diagnostic criteria for sporadic Creutzfeldt-Jakob disease a few retrospective studies and our clinical experience have suggested they are prominent and often occur early.

The objective of our study was to assess prospectively the neuropsychiatric features in sCJD (and their impact on caregivers) and compare them with five other neurodegenerative diseases: Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP), behavioral variant frontotemporal dementia (bvFTD) and semantic variant primary progressive aphasia (svPPA).

The Neuropsychiatric Inventory (NPI) was given at the first UCSF research visit to caregivers of 789 serial patients evaluated at the UCSF Memory and Aging Center from January 2000 through November 2016 who met diagnostic research criteria for one of the six neurodegenerative disorders. All subjects also had to have a Mini-Mental Status Evaluation (MMSE) and demographic data (age, sex, years of education).

We hypothesized that sCJD has a very prominent behavioral and neuropsychiatric profile, which might help distinguish it from other neurodegenerative diseases. Of our sCJD cohort (n=92), 97% had at least one NPI neuropsychiatric symptom, and half had at least six of the 12 NPI symptom categories, by their first research visit. The most common behavioral symptoms, occurring in more than half of sCJD patients, were: Appetite/Eating Disorders (68%), Apathy/Indifference (66%), Night-time Behaviors (53%), Aberrant Motor Behavior (53%) and Anxiety (52%). Even the least common behavior, Disinhibition, occurred in 19%. Compared to both DLB and bvFTD ­– two conditions with very prominent behavioral features and which include behavior in their diagnostic criteria – ­sCJD had significantly higher mean NPI FrequencyxSeverity product scores for Night-time Behaviors and Delusions; sCJD also had significantly higher scores for Hallucinations and Depression/Dysphoria than bvFTD and for Appetite/Eating Disorder, Aberrant Motor behavior and Agitation than DLB. sCJD had significantly worse FrequencyxSeverity scores than AD in three-quarters of NPI categories. Our data show that sCJD is a highly behavioral syndrome.

Although no neuropsychiatric symptom is pathognomonic for sCJD, certain symptoms might help differentiate sCJD from some other neurodegenerative diseases. Our findings support the inclusion of behavioral symptoms in sCJD diagnostic criteria.

prion disease, Jakob-Creutzfeldt disease, CJD, transmissible spongiform encephalopathy, management

Topic: creutzfeldt-jakob disease behavioral symptoms neurodegenerative disorders diagnosis creutzfeldt-jakob disease, sporadic

https://academic.oup.com/brain/advance-article-abstract/doi/10.1093/brain/awaf077/8098176?login=false

Singeltary 1999 “There have been people dying from CJD, with all the symptoms and pathological findings that resemble U.K. vCJD for some time.”

US scientists develop a possible test for BSE

BMJ 1999; 319 doi: https://doi.org/10.1136/bmj.319.7220.1312b (Published 13 November 1999) Cite this as: BMJ 1999;319:1312

Rapid Response:

Re: vCJD in the USA * BSE in U.S.

In reading the recent article in the BMJ about the potential BSE tests being developed in the U.S. and Bart Van Everbroeck reply. It does not surprize me, that the U.S. has been concealing vCJD. There have been people dying from CJD, with all the symptoms and pathological findings that resemble U.K. vCJD for some time. It just seems that when there is one found, they seem to change the clarical classification of the disease, to fit their agenda. I have several autopsies, stating kuru type amyloid plaques, one of the victims was 41 years of age. Also, my Mom died a most hideous death, Heidenhain Variant Creutzfeldt Jakob disease.

Her symptoms resemble that of all the U.K. vCJD victims. She would jerk so bad at times, it would take 3 of us to hold her down, while she screamed "God, what's wrong with me, why can't I stop this." 1st of symptoms to death, 10 weeks, she went blind in the first few weeks. But, then they told me that this was just another strain of sporadic CJD. They can call it what ever they want, but I know what I saw, and what she went through. Sporadic, simply means, they do not know.

My neighbors Mom also died from CJD. She had been taking a nutritional supplement which contained the following;

vacuum dried bovine BRAIN, bone meal, bovine EYE, veal bone, bovine liver powder, bovine adrenal, vacuum dried bovine kidney, and vacuum dried porcine stomach. As I said, this woman taking these nutritional supplements, died from CJD.

The particular batch of pills that was located, in which she was taking, was tested. From what I have heard, they came up negative, for the prion protein. But, in the same breath, they said their testing, may not have been strong enough to pick up the infectivity. Plus, she had been taking these type pills for years, so, could it have come from another batch?

CWD is just a small piece of a very big puzzle. I have seen while deer hunting, deer, squirrels and birds, eating from cattle feed troughs where they feed cattle, the high protein cattle by products, at least up until Aug. 4, 1997.

So why would it be so hard to believe that this is how they might become infected with a TSE. Or, even by potentially infected land. It's been well documented that it could be possible, from scrapie. Cats becoming infected with a TSE. Have you ever read the ingredients on the labels of cat and dog food? But, they do not put these tissues from these animals in pharmaceuticals, cosmetics, nutritional supplements, hGH, hPG, blood products, heart valves, and the many more products that come from bovine, ovine, or porcine tissues and organs. So, as I said, this CWD would be a small piece of a very big puzzle. But, it is here, and it most likely has killed. You see, greed is what caused this catastrophe, rendering and feeding practices. But, once Pandora's box was opened, the potential routes of infection became endless.

No BSE in the U.S.A.? I would not be so sure of that considering that since 1990;

Since 1990 the U.S. has raised 1,250,880,700 cattle;

Since 1990 the U.S. has ONLY checked 8,881 cattle brains for BSE, as of Oct. 4, 1999;

There are apprx. 100,000 DOWNER cattle annually in the U.S., that up until Aug. 4, 1997 went to the renders for feed;

Scrapie running rampant for years in the U.S., 950 infected FLOCKS, as of Aug. 1999;

Our feeding and rendering practices have mirrored that of the U.K. for years, some say it was worse. Everything from the downer cattle, to those scrapie infected sheep, to any roadkill, including the city police horse and the circus elephant went to the renders for feed and other products for consumption. Then they only implemented a partial feed ban on Aug. 4, 1997, but pigs, chickens, dogs, and cats, and humans were exempt from that ban. So they can still feed pigs and chickens those potentially TSE tainted by-products, and then they can still feed those by-products back to the cows. I believe it was Dr. Joe Gibbs, that said, the prion protein, can survive the digestinal track. So you have stopped nothing. It was proven in Oprah Winfrey's trial, that Cactus Cattle feeders, sent neurologically ill cattle, some with encephalopathy stamped on the dead slips, were picked up and sent to the renders, along with sheep carcasses. Speaking of autopsies, I have a stack of them, from CJD victims. You would be surprised of the number of them, who ate cow brains, elk brains, deer brains, or hog brains.

I believe all these TSE's are going to be related, and originally caused by the same greedy Industries, and they will be many. Not just the Renders, but you now see, that they are re-using medical devices that were meant for disposal. Some medical institutions do not follow proper auto- claving procedures (even Olympus has put out a medical warning on their endescopes about CJD, and the fact you cannot properly clean these instruments from TSE's), and this is just one product. Another route of infection.

Regardless what the Federal Government in the U.S. says. It's here, I have seen it, and the longer they keep sweeping it under the rug and denying the fact that we have a serious problem, one that could surpass aids (not now, but in the years to come, due to the incubation period), they will be responsible for the continued spreading of this deadly disease.

It's their move, it's CHECK, but once CHECKMATE has been called, how many thousands or millions, will be at risk or infected or even dead. You can't play around with these TSE's. I cannot stress that enough. They are only looking at body bags, and the fact the count is so low. But, then you have to look at the fact it is not a reportable disease in most states, mis-diagnosis, no autopsies performed. The fact that their one-in-a- million theory is a crude survey done about 5 years ago, that's a joke, under the above circumstances. A bad joke indeed........

The truth will come, but how many more have to die such a hideous death. It's the Government's call, and they need to make a serious move, soon. This problem, potential epidemic, is not going away, by itself.

Terry S. Singeltary Sr.

Bacliff, Texas 77518 USA

flounder@wt.net

Competing interests: No competing interests

https://www.bmj.com/rapid-response/2011/10/28/re-vcjd-usa-bse-us

Re: vCJD in the USA * BSE in U.S. BMJ 1999;319:1312 Singeltary

https://www.bmj.com/rapid-response/2011/10/28/re-vcjd-usa-bse-us

Singeltary 2000

BMJ 2000; 320 doi: https://doi.org/10.1136/bmj.320.7226.8/b (Published 01 January 2000) Cite this as: BMJ 2000;320:8

02 January 2000 Terry S Singeltary retired

Rapid Response:

U.S. Scientist should be concerned with a CJD epidemic in the U.S., as well...

In reading your short article about 'Scientist warn of CJD epidemic' news in brief Jan. 1, 2000. I find the findings in the PNAS old news, made famous again. Why is the U.S. still sitting on their butts, ignoring the facts? We have the beginning of a CJD epidemic in the U.S., and the U.S. Gov. is doing everything in it's power to conceal it.

The exact same recipe for B.S.E. existed in the U.S. for years and years. In reading over the Qualitative Analysis of BSE Risk Factors-1, this is a 25 page report by the USDA:APHIS:VS. It could have been done in one page. The first page, fourth paragraph says it all;

"Similarities exist in the two countries usage of continuous rendering technology and the lack of usage of solvents, however, large differences still remain with other risk factors which greatly reduce the potential risk at the national level."

Then, the next 24 pages tries to down-play the high risks of B.S.E. in the U.S., with nothing more than the cattle to sheep ratio count, and the geographical locations of herds and flocks. That's all the evidence they can come up with, in the next 24 pages.

Something else I find odd, page 16;

"In the United Kingdom there is much concern for a specific continuous rendering technology which uses lower temperatures and accounts for 25 percent of total output. This technology was _originally_ designed and imported from the United States. However, the specific application in the production process is _believed_ to be different in the two countries."

A few more factors to consider, page 15;

"Figure 26 compares animal protein production for the two countries. The calculations are based on slaughter numbers, fallen stock estimates, and product yield coefficients. This approach is used due to variation of up to 80 percent from different reported sources. At 3.6 million tons, the United States produces 8 times more animal rendered product than the United Kingdom."

"The risk of introducing the BSE agent through sheep meat and bone meal is more acute in both relative and absolute terms in the United Kingdom (Figures 27 and 28). Note that sheep meat and bone meal accounts for 14 percent, or 61 thousand tons, in the United Kingdom versus 0.6 percent or 22 thousand tons in the United States. For sheep greater than 1 year, this is less than one-tenth of one percent of the United States supply."

"The potential risk of amplification of the BSE agent through cattle meat and bone meal is much greater in the United States where it accounts for 59 percent of total product or almost 5 times more than the total amount of rendered product in the United Kingdom."

Considering, it would only take _one_ scrapie infected sheep to contaminate the feed. Considering Scrapie has run rampant in the U.S. for years, as of Aug. 1999, 950 scrapie infected flocks. Also, Considering only one quarter spoonful of scrapie infected material is lethal to a cow.

Considering all this, the sheep to cow ration is meaningless. As I said, it's 24 pages of B.S.e.

To be continued...

Terry S. Singeltary Sr. Bacliff, Texas USA

Competing interests: No competing interests

https://www.bmj.com/rapid-response/2011/10/28/us-scientist-should-be-concerned-cjd-epidemic-us-well

Diagnosis and Reporting of Creutzfeldt-Jakob Disease

Singeltary, Sr et al. JAMA.2001; 285:733-734. Flight. 285 No. 6, February 14, 2001 JAMA

Diagnosis and Reporting of Creutzfeldt-Jakob Disease

To the Editor:

In their Research Letter, Dr Gibbons and colleagues1 reported that the annual US death rate due to Creutzfeldt-Jakob disease (CJD) has been stable since 1985. These estimates, however, are based only on reported cases, and do not include misdiagnosed or preclinical boxes. It seems to me that misdiagnosis alone would drastically change these figures. An unknown number of persons with a diagnosis of Alzheimer disease in fact may have CJD, although only a small number of these patients receive the postmortem examination necessary to make this diagnosis. Furthermore, only a few states have made CJD reportable. Human and animal transmissible spongiform encephalopathies should be reportable nationally and internationally..

Terry S. Singeltary, Sr. Bacliff, Tex

1. Gibbons RV, Holman RC, Belay ED, Schonberger LB. Creutzfeldt-Jakob disease in the United States: 1979-1998. JAMA. 2000;284:2322-2323.

http://jama.jamanetwork.com/article.aspx?articleid=1031186

August 10, 2009

Greetings,

I would like to submit a review of past CJD surveillance in the USA, and the urgent need to make all human TSE in the USA a reportable disease, in every state, of every age group, and to make this mandatory immediately without further delay. The ramifications of not doing so will only allow this agent to spread further in the medical, dental, surgical arena's. North America seems to have the most species with documented Transmissible Spongiform Encephalopathy's, most all of which have been rendered and fed back to food producing animals and to humans for years. If you look at the statistics, sporadic CJD seems to be rising in the USA, and has been, with atypical cases of the sCJD. I find deeply disturbing in the year of 2009, that Human Transmissible Spongiform Encephalopathy of any strain and or phenotype, of all age groups, and I stress all age groups, because human TSE's do not know age, and they do not know borders. someone 56 years old, that has a human TSE, that has surgery, can pass this TSE agent on i.e. friendly fire, and or passing it forward, and there have been documented nvCJD in a 74 year old. Remembering also that only sporadic CJD has been documented to transmit via iatrogenic routes, until recently with the 4 cases of blood related transmission, of which the origin is thought to be nvCJD donors. However most Iatrogenic CJD cases are nothing more than sporadic CJD, until the source is proven, then it becomes Iatrogenic. An oxymoron of sorts, because all sporadic CJD is, are multiple forms, or strains, or phenotypes of Creutzfeldt Jakob Disease, that the route and source and species have not been confirmed and or documented. When will the myth of the UKBSEnvCJD only theory be put to bed for good. This theory in my opinion, and the following there from, as the GOLD STANDARD, has done nothing more than help spread this agent around the globe. Politics and money have caused the terrible consequences to date, and the fact that TSEs are a slow incubating death, but a death that is 100% certain for those that are exposed and live long enough to go clinical. once clinical, there is no recourse, to date. But, while sub-clinical, how many can one exposed human infect? Can humans exposed to CWD and scrapie strains pass it forward as some form of sporadic CJD in the surgical and medical arenas? why must we wait decades and decades to prove this point, only to expose millions needlessly, only for the sake of the industries involved? would it not have been prudent from the beginning to just include all TSE's, and rule them out from there with transmission studies and change policies there from, as opposed to doing just the opposite? The science of TSE's have been nothing more than a political circus since the beginning, and for anyone to still believe in this one strain, one group of bovines, in one geographical location, with only one age group of human TSE i.e. nvCJD myth, for anyone to believe this today only enhances to spreading of these human and animal TSE's. This is exactly why we have been in this quagmire.

The ones that believe that there is a spontaneous CJD in 85%+ of all cases of human TSE, and the ones that do not believe that cattle can have this same phenomenon, are two of the same, the industry, and so goes the political science aspect of this tobacco and or asbestos scenario i.e. follow the money. I could go into all angles of this man made nightmare, the real facts and science, for instance, the continuing rendering technology and slow cooking with low temps that brewed this stew up, and the fact that THE USA HAD THIS TECHNOLOGY FIRST AND SHIPPED IT TO THE U.K. SOME 5 YEARS BEFORE THE U.S. STARTED USING THE SAME TECHNOLOGY, to save on fuel cost. This is what supposedly amplified the TSE agent via sheep scrapie, and spread via feed in the U.K. bovine, and other countries exporting the tainted product. BUT most everyone ignores this fact, and the fact that the U.S. has been recycling more TSE, from more species with TSEs, than any other country documented, but yet, it's all spontaneous, and the rise in sporadic CJD in the U.S. is a happenstance of bad luck ??? I respectfully disagree. To top that all off, the infamous BSE-FIREWALL that the USDA always brags about was nothing more than ink on paper, and I can prove this. YOU can ignore it, but this is FACT (see source, as late as 2007, in one recall alone, some 10,000,000 MILLION POUNDS OF BANNED MAD COW FEED WENT OUT INTO COMMERCE TO BE FED OUT, and most was never recovered. This was banned blood laced, meat and bone meal. 2006 was a banner year for banned mad cow protein going into commerce in the U.S. (see source of FDA feed ban warning letter below). I stress that the August 4, 1997 USA mad cow feed ban and this infamous BSE firewall, was nothing more than ink on paper, it was never enforceable.

I propose that the current diagnostic criteria for human TSEs only enhances and helps the spreading of human TSE from the continued belief of the UKBSEnvCJD only theory in 2009. With all the science to date refuting it, to continue to validate this old myth, will only spread this TSE agent through a multitude of potential routes and sources i.e. consumption, medical i.e., surgical, blood, dental, endoscopy, optical, nutritional supplements, cosmetics etc. I propose as with Aguzzi, Asante, Collinge, Caughey, Deslys, Dormont, Gibbs, Gajdusek, Ironside, Manuelidis, Marsh, et al and many more, that the world of TSE Transmissible Spongiform Encephalopathy is far from an exact science, but there is enough proven science to date that this myth should be put to rest once and for all, and that we move forward with a new classification for human and animal TSE that would properly identify the infected species, the source species, and then the route. This would further have to be broken down to strain of species and then the route of transmission would further have to be broken down. Accumulation and Transmission are key to the threshold from sub- clinical to clinical disease, and key to all this, is to stop the amplification and transmission of this agent, the spreading of, no matter what strain. In my opinion, to continue with this myth that the U.K. strain of BSE one strain TSE in cows, and the nv/v CJD one strain TSE humans, and the one geographical location source i.e. U.K., and that all the rest of human TSE are just one single strain i.e. sporadic CJD, a happenstance of bad luck that just happens due to a twisted protein that just twisted the wrong way, IN 85%+ OF ALL HUMAN TSEs, when to date there are 6 different phenotypes of sCJD, and growing per Gambetti et al, and that no other animal TSE transmits to humans ??? With all due respect to all Scientist that believe this, I beg to differ. To continue with this masquerade will only continue to spread, expose, and kill, who knows how many more in the years and decades to come. ONE was enough for me, My Mom, hvCJD i.e. Heidenhain Variant CJD, DOD 12/14/97 confirmed, which is nothing more than another mans name added to CJD, like CJD itself, Jakob and Creutzfeldt, or Gerstmann-Straussler-Scheinker syndrome, just another CJD or human TSE, named after another human. WE are only kidding ourselves with the current diagnostic criteria for human and animal TSE, especially differentiating between the nvCJD vs the sporadic CJD strains and then the GSS strains and also the FFI fatal familial insomnia strains or the ones that mimics one or the other of those TSE? Tissue infectivity and strain typing of the many variants of the human and animal TSEs are paramount in all variants of all TSE. There must be a proper classification that will differentiate between all these human TSE in order to do this. With the CDI and other more sensitive testing coming about, I only hope that my proposal will some day be taken seriously. ...

https://journals.plos.org/plosone/article/comment?id=10.1371/annotation/04ce2b24-613d-46e6-9802-4131e2bfa6fd

doi:10.1016/S1473-3099(03)00715-1 Copyright © 2003 Published by Elsevier Ltd. Newsdesk

Tracking spongiform encephalopathies in North America

Xavier Bosch

Available online July 29, 2003.

Volume 3, Issue 8, August 2003, Page 463

“My name is Terry S Singeltary Sr, and I live in Bacliff, Texas. I lost my mom to hvCJD (Heidenhain variant CJD) and have been searching for answers ever since. What I have found is that we have not been told the truth. CWD in deer and elk is a small portion of a much bigger problem..” ........................

http://www.thelancet.com/journals/laninf/article/PIIS1473309903007151/fulltext

http://download.thelancet..com/pdfs/journals/1473-3099/PIIS1473309903007151.pdf

https://web.archive.org/web/20230315063500/https://www.thelancet.com/pdfs/journals/1473-3099/PIIS1473309903007151.pdf

RE-Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States

Terry S. Singeltary, retired (medically)

Published March 26, 2003

March 26, 2003

Terry S. Singeltary, retired (medically) CJD WATCH

I lost my mother to hvCJD (Heidenhain Variant CJD). I would like to comment on the CDC's attempts to monitor the occurrence of emerging forms of CJD. Asante, Collinge et al [1] have reported that BSE transmission to the 129-methionine genotype can lead to an alternate phenotype that is indistinguishable from type 2 PrPSc, the commonest sporadic CJD. However, CJD and all human TSEs are not reportable nationally. CJD and all human TSEs must be made reportable in every state and internationally. I hope that the CDC does not continue to expect us to still believe that the 85%+ of all CJD cases which are sporadic are all spontaneous, without route/source. We have many TSEs in the USA in both animal and man. CWD in deer/elk is spreading rapidly and CWD does transmit to mink, ferret, cattle, and squirrel monkey by intracerebral inoculation. With the known incubation periods in other TSEs, oral transmission studies of CWD may take much longer. Every victim/family of CJD/TSEs should be asked about route and source of this agent. To prolong this will only spread the agent and needlessly expose others. In light of the findings of Asante and Collinge et al, there should be drastic measures to safeguard the medical and surgical arena from sporadic CJDs and all human TSEs. I only ponder how many sporadic CJDs in the USA are type 2 PrPSc?

http://n.neurology.org/content/re-monitoring-occurrence-emerging-forms-creutzfeldt-jakob-disease-united-states

14th ICID International Scientific Exchange Brochure - Final Abstract Number: ISE.114

Session: International Scientific Exchange

Transmissible Spongiform encephalopathy (TSE) animal and human TSE in North America update October 2009

T. Singeltary Bacliff, TX, USA

Background: An update on atypical BSE and other TSE in North America. Please remember, the typical U.K. c-BSE, the atypical l-BSE (BASE), and h-BSE have all been documented in North America, along with the typical scrapie's, and atypical Nor-98 Scrapie, and to date, 2 different strains of CWD, and also TME. All these TSE in different species have been rendered and fed to food producing animals for humans and animals in North America (TSE in cats and dogs ?), and that the trading of these TSEs via animals and products via the USA and Canada has been immense over the years, decades.

Methods: 12 years independent research of available data

Results: I propose that the current diagnostic criteria for human TSEs only enhances and helps the spreading of human TSE from the continued belief of the UKBSEnvCJD only theory in 2009. With all the science to date refuting it, to continue to validate this old myth, will only spread this TSE agent through a multitude of potential routes and sources i.e. consumption, medical i.e., surgical, blood, dental, endoscopy, optical, nutritional supplements, cosmetics etc.

Conclusion: I would like to submit a review of past CJD surveillance in the USA, and the urgent need to make all human TSE in the USA a reportable disease, in every state, of every age group, and to make this mandatory immediately without further delay. The ramifications of not doing so will only allow this agent to spread further in the medical, dental, surgical arena's. Restricting the reporting of CJD and or any human TSE is NOT scientific. Iatrogenic CJD knows NO age group, TSE knows no boundaries. I propose as with Aguzzi, Asante, Collinge, Caughey, Deslys, Dormont, Gibbs, Gajdusek, Ironside, Manuelidis, Marsh, et al and many more, that the world of TSE Transmissible Spongiform Encephalopathy is far from an exact science, but there is enough proven science to date that this myth should be put to rest once and for all, and that we move forward with a new classification for human and animal TSE that would properly identify the infected species, the source species, and then the route.

http://ww2.isid.org/Downloads/14th_ICID_ISE_Abstracts.pdf

https://web.archive.org/web/20110417201250/http://ww2.isid.org/Downloads/14th_ICID_ISE_Abstracts.pdf

AS implied in the Inset 25 we must not _ASSUME_ that transmission of BSE to other species will invariably present pathology typical of a scrapie-like disease.

snip...

http://web.archive.org/web/20060307063542/http://www.bseinquiry.gov.uk/files/yb/1991/01/04004001.pdf

Alzheimer’s disease and Transmissible Spongiform Encephalopathy prion disease, Iatrogenic, what if ?

Posted by flounder on 05 Nov 2014 at 21:27 GMT

https://journals.plos.org/plosone/article/comment?id=10.1371/annotation/933cc83a-a384-45c3-b3b2-336882c30f9d

http://journals.plos.org/plosone/article/comments?id=10.1371/journal.pone.0111492

SUNDAY, MARCH 23, 2025

Creutzfeldt Jakob Disease TSE Prion Increasing 2025 Update

https://creutzfeldt-jakob-disease.blogspot.com/2025/03/creutzfeldt-jakob-disease-tse-prion.html

https://creutzfeldt-jakob-disease.blogspot.com/2024/12/creutzfeldt-jacob-disease-cjd-bse-cwd.html

https://creutzfeldt-jakob-disease.blogspot.com/

terry