Saturday, July 26, 2008

Creutzfeldt-Jakob Disease in Recipients of Corneal Transplants

Creutzfeldt-Jakob Disease in Recipients of Corneal Transplants.

Case Report

Cornea. 27(7):851-854, August 2008. Maddox, Ryan A MPH *; Belay, Ermias D MD *; Curns, Aaron T MPH +; Zou, Wen-Quan MD, PhD ++; Nowicki, Scott MPH [S]; Lembach, Richard G MD [P]; Geschwind, Michael D MD, PhD **; Haman, Aissa MD **; Shinozaki, Naoshi ++; Nakamura, Yosikazu MD ++++; Borer, Mark J CEBT [S][S]; Schonberger, Lawrence B MD * Abstract: Purpose: Creutzfeldt-Jakob disease (CJD) transmission has been documented to occur from the use of corneal grafts. We report 4 cases of CJD with a history of corneal transplantation and assess the frequency of coincidental CJD among corneal transplant recipients.

Methods: Medical records and eye bank documents were reviewed. Genetic and neuropathologic tests on available specimens were performed at the National Prion Disease Pathology Surveillance Center. Statistical analyses were used to determine the expected number of coincidental CJD cases among the US population with a history of corneal transplantation.

Results: Four CJD decedents with histories of corneal transplantation were identified: 3 from the United States and 1 from Japan. The time from transplant to onset of CJD symptoms ranged from 2 years, 11 months to 18 years. Available eye bank records did not suggest evidence of neurologic illness in the donors. Using corneal transplantation and CJD death data from 1990 through 2006, statistical analyses suggest that a case of coincidental sporadic CJD will occur among the population of corneal transplant recipients approximately every 1.5 years.

Conclusions: It is likely that these 4 recipients of transplanted corneas had sporadic CJD. Because of the many corneal transplantations performed each year in the United States, occasional cases of sporadic CJD in this population are expected.

(C) 2008 Lippincott Williams & Wilkins, Inc.;jsessionid=LL1QFs6NXh3P3P29QFYTJJsQ34sLm59pnnT4DQ1sNRBhMLMyJ561!1629792715!181195629!8091!-1

> Because of the many corneal transplantations performed each year in the United States, occasional cases of sporadic CJD in this population are expected.

gee wiz, i feel much better, and i am sure any recipient of a cornea will too. ...not. ...TSS

CJD, they eye's have it and they could be stealing them from your loved one

Subject: RE-The Eyes Have It (cjd) and they could be stealing them from your loved one... "pay back time" Date: Sat, 16 Sep 2000 10:04:26 -0700 From: "Terry S. Singeltary Sr." Reply-To: Bovine Spongiform Encephalopathy To:

######### Bovine Spongiform Encephalopathy #########

Greetings List Members,

I hate to keep kicking a madcow, but this still is very disturbing to me. Not only for the recipient of the cornea's, but as well, for the people whom would be operated on, using the same tools that were used to put those stolen cornea's in the recipient with. ...

snip...see full text ;

Saturday, January 26, 2008

Thursday, July 24, 2008
Prion diseases are efficiently transmitted by blood transfusion in sheep
Submitted April 18, 2008 Accepted June 28, 2008

vCJD questionnaire


why is a cjd questionnaire not listed on the cjd foundation 'forms' site with the rest of their forms ???

i thought they had one now going out to all families of victims of a human TSE???

this is very important that a _written_ cjd questionnaire, asking extensive questions pertaining to any potential route and source of the TSE agent be submitted to every family of a victim of a human TSE. this is key to finding cause. so why is this still so difficult? are the families of CJD victims getting these written cjd questionnaires??? i hope so....

2008 The statistical incidence of CJD cases in the United States has been revised to reflect that there is

_one case per 9000 in adults age 55 and older_.

Eighty-five percent of the cases are sporadic, meaning there is no known cause at present.



Sunday, July 20, 2008 Red Cross told to fix blood collection or face charges 15 years after warnings issued, few changes made to ensure safety


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