Psychiatric Symptoms in Patients With Sporadic Creutzfeldt-Jakob Disease in Germany
Psychiatric Symptoms in Patients With Sporadic Creutzfeldt-Jakob Disease in
Germany
Anna Krasnianski, MD; Geeske T. Bohling; Markus Harden; and Inga Zerr,
MD
J Clin Psychiatry 2015 10.4088/JCP.13m08915 © Copyright 2015 Physicians
Postgraduate Press, Inc. Background: Psychiatric symptoms in sporadic
Creutzfeldt-Jakob disease (sCJD) are still not sufficiently evaluated.
Aim: To describe psychiatric symptoms in sCJD with respect to molecular
subtype.
Method: Patients in this retrospective study were classified according to
established diagnostic criteria. 248 sCJD patients with known molecular subtype
were recruited from January 1993 to December 2004 and investigated. Psychiatric
symptoms were defined according to Möller and colleagues and the AMDP system
(Study Group for Methods and Documentation in Psychiatry) and were collected by
direct examination by study physicians or extracted from medical documentation.
Our data were compared with published data on variant CJD (vCJD).
Results: Psychiatric symptoms were common in sCJD patients (90%) and mostly
found already at the disease onset (agitation in 64% of the patients,
hallucinations in 45%, anxiety in 50%, depression in 37%). All psychiatric
symptoms but illusions were found early in the disease course. Psychiatric
symptoms in sCJD were less frequent than in vCJD.
Conclusions: We provide the first detailed analysis of psychiatric symptoms
in a large group of patients with sCJD with respect to differences concerning
frequency and time point of occurrence of psychiatric symptoms between molecular
subtypes. These data suggest that psychiatric symptoms occurring early in the
disease course are common not only in vCJD but also in other CJD types.
Sunday, May 03, 2015
Unusual Case of Sporadic Creutzfeldt–Jakob Disease Subtype VV1
Wednesday, April 08, 2015
Sporadic Creutzfeldt-Jakob Disease MM1+2C and MM1 Are Identical in
Transmission Properties
Wednesday, February 04, 2009
Creutzfeldt-Jacob disease presenting as severe depression: a case report
Sunday, August 09, 2009
*** CJD...Straight talk with...James Ironside...and...Terry Singeltary...
2009
Tuesday, August 18, 2009
*** BSE-The Untold Story - joe gibbs and singeltary 1999 – 2009
I said this over a decade ago, and I believe it still holds true today
;
just speaking of human TSE's; "different strains (of same disease) in
different species (of the same disease), different routes of infection (of same
disease), different infectivity levels (dose rate) of the (same disease),
different parts of the brain affected (of the same disease), different genetic
make-up of humans (with same disease) = different symptoms, different lengths of
illness from 1st onset of illness to death, (of the same disease) + different
cultures = different geographical locations = different strains (of same
disease)...TSS"
PRION2015 FORT COLLINS
Wednesday May 27
14:45 Jean-Phillipe Deslys Atomic Energy Commission, France,
Transmission of prions to primates after extended silent incubation
periods: * IMPLICATIONS FOR BSE AND SCRAPIE RISK ASSESSMENT IN HUMAN
POPULATIONS.
16:45
Quingzhong Kong Case Western Reserve University
Zoonotic Potential of CWD Prions
*** Kuru Video ***
Kuru: The Science and The Sorcery
*** Scrapie Video
*** Human Mad Cow Video
*** USA sporadic CJD MAD COW DISEASE HAS HUGE PROBLEM Video
2014
***Moreover, L-BSE has been transmitted more easily to transgenic mice
overexpressing a human PrP [13,14] or to primates [15,16] than C-BSE.
***It has been suggested that some sporadic CJD subtypes in humans may
result from an exposure to the L-BSE agent.
*** Lending support to this hypothesis, pathological and biochemical
similarities have been observed between L-BSE and an sCJD subtype (MV genotype
at codon 129 of PRNP) [17], and between L-BSE infected non-human primate and
another sCJD subtype (MM genotype) [15].
snip...
Monday, October 10, 2011
EFSA Journal 2011 The European Response to BSE: A Success Story
snip...
EFSA and the European Centre for Disease Prevention and Control (ECDC)
recently delivered a scientific opinion on any possible epidemiological or
molecular association between TSEs in animals and humans (EFSA Panel on
Biological Hazards (BIOHAZ) and ECDC, 2011). This opinion confirmed Classical
BSE prions as the only TSE agents demonstrated to be zoonotic so far
*** but the possibility that a small proportion of human cases so far
classified as "sporadic" CJD are of zoonotic origin could not be excluded.
*** Moreover, transmission experiments to non-human primates suggest that
some TSE agents in addition to Classical BSE prions in cattle (namely L-type
Atypical BSE, Classical BSE in sheep, transmissible mink encephalopathy (TME)
and chronic wasting disease (CWD) agents) might have zoonotic potential.
snip...
Thursday, August 12, 2010
Seven main threats for the future linked to prions
First threat
The TSE road map defining the evolution of European policy for protection
against prion diseases is based on a certain numbers of hypotheses some of which
may turn out to be erroneous. In particular, a form of BSE (called atypical
Bovine Spongiform Encephalopathy), recently identified by systematic testing in
aged cattle without clinical signs, may be the origin of classical BSE and thus
potentially constitute a reservoir, which may be impossible to eradicate if a
sporadic origin is confirmed.
*** Also, a link is suspected between atypical BSE and some apparently
sporadic cases of Creutzfeldt-Jakob disease in humans.
*** These atypical BSE cases constitute an unforeseen first threat that
could sharply modify the European approach to prion diseases.
Second threat
snip...
*** Creutzfeldt-Jakob Disease Public Health Crisis VIDEO
Tuesday, December 16, 2014
Evidence for zoonotic potential of ovine scrapie prions
Hervé Cassard,1, n1 Juan-Maria Torres,2, n1 Caroline Lacroux,1, Jean-Yves
Douet,1, Sylvie L. Benestad,3, Frédéric Lantier,4, Séverine Lugan,1, Isabelle
Lantier,4, Pierrette Costes,1, Naima Aron,1, Fabienne Reine,5, Laetitia
Herzog,5, Juan-Carlos Espinosa,2, Vincent Beringue5, & Olivier
Andréoletti1, Affiliations Contributions Corresponding author Journal name:
Nature Communications Volume: 5, Article number: 5821 DOI:
doi:10.1038/ncomms6821 Received 07 August 2014 Accepted 10 November 2014
Published 16 December 2014 Article tools Citation Reprints Rights &
permissions Article metrics
Abstract
Although Bovine Spongiform Encephalopathy (BSE) is the cause of variant
Creutzfeldt Jakob disease (vCJD) in humans, the zoonotic potential of scrapie
prions remains unknown. Mice genetically engineered to overexpress the human
prion protein (tgHu) have emerged as highly relevant models for gauging the
capacity of prions to transmit to humans. These models can propagate human
prions without any apparent transmission barrier and have been used used to
confirm the zoonotic ability of BSE. Here we show that a panel of sheep scrapie
prions transmit to several tgHu mice models with an efficiency comparable to
that of cattle BSE. The serial transmission of different scrapie isolates in
these mice led to the propagation of prions that are phenotypically identical to
those causing sporadic CJD (sCJD) in humans. These results demonstrate that
scrapie prions have a zoonotic potential and raise new questions about the
possible link between animal and human prions.
Subject terms: Biological sciences• Medical research At a glance
why do we not want to do TSE transmission studies on chimpanzees $
5. A positive result from a chimpanzee challenged severly would likely
create alarm in some circles even if the result could not be interpreted for
man. I have a view that all these agents could be transmitted provided a large
enough dose by appropriate routes was given and the animals kept long enough.
Until the mechanisms of the species barrier are more clearly understood it might
be best to retain that hypothesis.
snip...
R. BRADLEY
Suspect symptoms
What if you can catch old-fashioned CJD by eating meat from a sheep
infected with scrapie?
28 Mar 01 Most doctors believe that sCJD is caused by a prion protein
deforming by chance into a killer. But Singeltary thinks otherwise. He is one of
a number of campaigners who say that some sCJD, like the variant CJD related to
BSE, is caused by eating meat from infected animals. Their suspicions have
focused on sheep carrying scrapie, a BSE-like disease that is widespread in
flocks across Europe and North America.
Now scientists in France have stumbled across new evidence that adds weight
to the campaigners' fears. To their complete surprise, the researchers found
that one strain of scrapie causes the same brain damage in mice as sCJD.
"This means we cannot rule out that at least some sCJD may be caused by
some strains of scrapie," says team member Jean-Philippe Deslys of the French
Atomic Energy Commission's medical research laboratory in Fontenay-aux-Roses,
south-west of Paris. Hans Kretschmar of the University of Göttingen, who
coordinates CJD surveillance in Germany, is so concerned by the findings that he
now wants to trawl back through past sCJD cases to see if any might have been
caused by eating infected mutton or lamb...
2001
Suspect symptoms
What if you can catch old-fashioned CJD by eating meat from a sheep
infected with scrapie?
28 Mar 01
Like lambs to the slaughter
31 March 2001
by Debora MacKenzie Magazine issue 2284.
FOUR years ago, Terry Singeltary watched his mother die horribly from a
degenerative brain disease. Doctors told him it was Alzheimer's, but Singeltary
was suspicious. The diagnosis didn't fit her violent symptoms, and he demanded
an autopsy. It showed she had died of sporadic Creutzfeldt-Jakob disease.
Most doctors believe that sCJD is caused by a prion protein deforming by
chance into a killer. But Singeltary thinks otherwise. He is one of a number of
campaigners who say that some sCJD, like the variant CJD related to BSE, is
caused by eating meat from infected animals. Their suspicions have focused on
sheep carrying scrapie, a BSE-like disease that is widespread in flocks across
Europe and North America.
Now scientists in France have stumbled across new evidence that adds weight
to the campaigners' fears. To their complete surprise, the researchers found
that one strain of scrapie causes the same brain damage in mice as sCJD.
"This means we cannot rule out that at least some sCJD may be caused by
some strains of scrapie," says team member Jean-Philippe Deslys of the French
Atomic Energy Commission's medical research laboratory in Fontenay-aux-Roses,
south-west of Paris. Hans Kretschmar of the University of Göttingen, who
coordinates CJD surveillance in Germany, is so concerned by the findings that he
now wants to trawl back through past sCJD cases to see if any might have been
caused by eating infected mutton or lamb.
Scrapie has been around for centuries and until now there has been no
evidence that it poses a risk to human health. But if the French finding means
that scrapie can cause sCJD in people, countries around the world may have
overlooked a CJD crisis to rival that caused by BSE.
Deslys and colleagues were originally studying vCJD, not sCJD. They
injected the brains of macaque monkeys with brain from BSE cattle, and from
French and British vCJD patients. The brain damage and clinical symptoms in the
monkeys were the same for all three. Mice injected with the original sets of
brain tissue or with infected monkey brain also developed the same symptoms.
As a control experiment, the team also injected mice with brain tissue from
people and animals with other prion diseases: a French case of sCJD; a French
patient who caught sCJD from human-derived growth hormone; sheep with a French
strain of scrapie; and mice carrying a prion derived from an American scrapie
strain. As expected, they all affected the brain in a different way from BSE and
vCJD. But while the American strain of scrapie caused different damage from
sCJD, the French strain produced exactly the same pathology.
"The main evidence that scrapie does not affect humans has been
epidemiology," says Moira Bruce of the neuropathogenesis unit of the Institute
for Animal Health in Edinburgh, who was a member of the same team as Deslys.
"You see about the same incidence of the disease everywhere, whether or not
there are many sheep, and in countries such as New Zealand with no scrapie." In
the only previous comparisons of sCJD and scrapie in mice, Bruce found they were
dissimilar.
But there are more than 20 strains of scrapie, and six of sCJD. "You would
not necessarily see a relationship between the two with epidemiology if only
some strains affect only some people," says Deslys. Bruce is cautious about the
mouse results, but agrees they require further investigation. Other trials of
scrapie and sCJD in mice, she says, are in progress.
People can have three different genetic variations of the human prion
protein, and each type of protein can fold up two different ways. Kretschmar has
found that these six combinations correspond to six clinical types of sCJD: each
type of normal prion produces a particular pathology when it spontaneously
deforms to produce sCJD.
But if these proteins deform because of infection with a disease-causing
prion, the relationship between pathology and prion type should be different, as
it is in vCJD. "If we look at brain samples from sporadic CJD cases and find
some that do not fit the pattern," says Kretschmar, "that could mean they were
caused by infection."
There are 250 deaths per year from sCJD in the US, and a similar incidence
elsewhere. Singeltary and other US activists think that some of these people
died after eating contaminated meat or "nutritional" pills containing dried
animal brain. Governments will have a hard time facing activists like Singeltary
if it turns out that some sCJD isn't as spontaneous as doctors have insisted.
Deslys's work on macaques also provides further proof that the human
disease vCJD is caused by BSE. And the experiments showed that vCJD is much more
virulent to primates than BSE, even when injected into the bloodstream rather
than the brain. This, says Deslys, means that there is an even bigger risk than
we thought that vCJD can be passed from one patient to another through
contaminated blood transfusions and surgical instruments.
Thursday, March 20, 2014
CHRONIC WASTING DISEASE CWD TSE PRION OF CERVID AND THE POTENTIAL FOR HUMAN
TRANSMISSION THEREFROM 2014
Tuesday, July 01, 2014
*** CHRONIC WASTING DISEASE CWD TSE PRION DISEASE, GAME FARMS, AND
POTENTIAL RISK FACTORS THERE FROM ***
Thursday, July 03, 2014
*** How Chronic Wasting Disease is affecting deer population and what’s the
risk to humans and pets? ***
Thursday
CWD TO HUMANS, AND RISK FACTORS THERE FROM (see latest science)
Tuesday, November 04, 2014
*** Six-year follow-up of a point-source exposure to CWD contaminated
venison in an Upstate New York community: risk behaviours and health outcomes
2005–2011
Thursday, April 30, 2015
Immediate and ongoing detection of prions in the blood of hamsters and deer
following oral, nasal, or blood inoculations
Friday, January 30, 2015
*** Scrapie: a particularly persistent pathogen ***
Sunday, April 12, 2015
*** Research Project: Transmission, Differentiation, and Pathobiology of
Transmissible Spongiform Encephalopathies 2014 Annual Report ***
http://transmissiblespongiformencephalopathy.blogspot.com/2015/04/research-project-transmission.html
Saturday, April 11, 2015
*** ISU veterinary researchers study retinal scans as early detection
method for mad cow disease
Sunday, November 23, 2014
*** Confirmed Variant Creutzfeldt-Jakob Disease (variant CJD) Case in Texas
in June 2014 confirmed as USA case NOT European ***
Monday, November 3, 2014
USA CJD TSE PRION UNIT, TEXAS, SURVEILLANCE UPDATE NOVEMBER 2014
National Prion Disease Pathology Surveillance Center Cases Examined1
(October 7, 2014)
***6 Includes 11 cases in which the diagnosis is pending, and 19
inconclusive cases;
***7 Includes 12 (11 from 2014) cases with type determination pending in
which the diagnosis of vCJD has been excluded.
***The sporadic cases include 2660 cases of sporadic Creutzfeldt-Jakob
disease (sCJD),
***50 cases of Variably Protease-Sensitive Prionopathy (VPSPr)
***and 21 cases of sporadic Fatal Insomnia (sFI).
Thursday, January 15, 2015
41-year-old Navy Commander with sporadic Creutzfeldt–Jakob disease CJD TSE
Prion: Case Report
Subject: *** Becky Lockhart 46, Utah’s first female House speaker, dies
diagnosed with the extremely rare Creutzfeldt-Jakob disease aka mad cow type
disease
what is CJD ? just ask USDA inc., and the OIE, they are still feeding the
public and the media industry fed junk science that is 30 years old.
why doesn’t some of you try reading the facts, instead of rubber stamping
everything the USDA inc says.
sporadic CJD has now been linked to BSE aka mad cow disease, Scrapie, and
there is much concern now for CWD and risk factor for humans.
My sincere condolences to the family and friends of the House Speaker Becky
Lockhart. I am deeply saddened hear this.
with that said, with great respect, I must ask each and every one of you
Politicians that are so deeply saddened to hear of this needless death of the
Honorable House Speaker Becky Lockhart, really, cry me a friggen river. I am
seriously going to ask you all this...I have been diplomatic for about 17 years
and it has got no where. people are still dying. so, are you all stupid or
what??? how many more need to die ??? how much is global trade of beef and other
meat products that are not tested for the TSE prion disease, how much and how
many bodies is this market worth?
Saturday, January 17, 2015
*** Becky Lockhart 46, Utah’s first female House speaker, dies diagnosed
with the extremely rare Creutzfeldt-Jakob disease
*** ALERT new variant Creutzfeldt Jakob Disease nvCJD or vCJD, sporadic CJD
strains, TSE prion aka Mad Cow Disease United States of America Update December
14, 2014 Report ***
Tuesday, November 04, 2014
Towards an Age-Dependent Transmission Model of Acquired and Sporadic
Creutzfeldt-Jakob Disease
Thursday, January 22, 2015
Transmission properties of atypical Creutzfeldt-Jakob disease: a clue to
disease etiology?
Sunday, July 06, 2014
Dietary Risk Factors for Sporadic Creutzfeldt-Jakob Disease: A Confirmatory
Case-Control Study
Conclusions—The a priori hypotheses were supported.
*Consumption of various meat products may be one method of transmission of
the infectious agent for sCJD.
PLEASE REMEMBER ;
The Akron, Ohio-based CJD Foundation said the Center for Disease Control
revised that number in October of 2004 to about one in 9,000 CJD cases per year
in the population group age 55 and older.
HAVE YOU GOT YOUR CJD QUESTIONNAIRE ASKING REAL QUESTIONS PERTAINING TO
ROUTE AND SOURCE OF THE TSE AGENT THAT KILLED YOUR LOVED ONE ???
if not, why not...
Friday, November 30, 2007
CJD QUESTIONNAIRE USA CWRU AND CJD FOUNDATION
Friday, January 10, 2014
vpspr, sgss, sffi, TSE, an iatrogenic by-product of gss, ffi, familial type
prion disease, what it ???
Self-Propagative Replication of Ab Oligomers Suggests Potential
Transmissibility in Alzheimer Disease
Received July 24, 2014; Accepted September 16, 2014; Published November 3,
2014
Singeltary comment ;
Saturday, December 13, 2014
Terry S. Singeltary Sr. Publications TSE prion disease
Diagnosis and Reporting of Creutzfeldt-Jakob Disease
Singeltary, Sr et al. JAMA.2001; 285: 733-734. Vol. 285 No. 6, February 14,
2001 JAMA
snip...
Tuesday, April 14, 2015
Transmissible Spongiform Encephalopthy TSE Prion Disease
Wednesday, April 15, 2015
KURU Transmissible Spongiform Encephalopthy TSE Prion Disease
Sunday, May 3, 2015
PRION2015 FORT COLLINS
Thursday, July 10, 2008
A New Prionopathy update July 10, 2008
snip...
DOES ANYONE BESIDES ME SEE A PATTERN YET ???
Vickey Rimmer, 16, DID NOT DIE FROM nvCJD, she died from a form of sporadic
CJD, whatever the hell that is. and there have been 16 year old die from
sporadic CJD in the USA as well.
SIMPLY PUT, the ukbsenvcjd only theory was wrong from day one. the elderly
are expendable, pets and kids are not.
Science was dictated by 'big buisness' after the Vickey Rimmer case with
the ukbsenvcjd only myth.
snip...
Sporadic creutzfeldt-jakob disease in two adolescents
see full text sporadic CJD the big lie;
snip...
IT seems we have come full circle from the 'ORIGINAL 10' i.e. the 1st 10
adolescents in the UKBSEnvCJD only theory. and now we find us at the 1st 10 in
USA, or is it the first 10, or the tip of the iceburg, many that went
undocumented ???
lets look at the full circle, to date ;
Sunday, August 10, 2008
*** A New Prionopathy OR more of the same old BSe and sporadic CJD
full text ;
Wednesday, October 09, 2013
WHY THE UKBSEnvCJD ONLY THEORY IS SO POPULAR IN IT'S FALLACY, £41,078,281
in compensation
Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in
the United States 2003 revisited 2009
Saturday, July, 18, 2009
Greetings,
I would like to submit a review of past CJD surveillance in the USA, and
the urgent need to make all human TSE in the USA a reportable disease, in every
state, of every age group, and to make this mandatory immediately without
further delay. The ramifications of not doing so will only allow this agent to
spread further in the medical, dental, surgical arena’s. North America seems to
have the most species with documented Transmissible Spongiform Encephalopathy's,
most all of which have been rendered and fed back to food producing animals and
to humans for years. If you look at the statistics, sporadic CJD seems to be
rising in the USA, and has been, with atypical cases of the sCJD. I find deeply
disturbing in the year of 2009, that Human Transmissible Spongiform
Encephalopathy of any strain and or phenotype, of all age groups, and I stress
all age groups, because human TSE's do not know age, and they do not know
borders. someone 56 years old, that has a human TSE, that has surgery, can pass
this TSE agent on i.e. friendly fire, and or passing it forward, and there have
been documented nvCJD in a 74 year old. Remembering also that only sporadic CJD
has been documented to transmit via iatrogenic routes, until recently with the 4
cases of blood related transmission, of which the origin is thought to be nvCJD
donors. However most Iatrogenic CJD cases are nothing more than sporadic CJD,
until the source is proven, then it becomes Iatrogenic. An oxymoron of sorts,
because all sporadic CJD is, are multiple forms, or strains, or phenotypes of
Creutzfeldt Jakob Disease, that the route and source and species have not been
confirmed and or documented. When will the myth of the UKBSEnvCJD only theory be
put to bed for good. This theory in my opinion, and the following there from, as
the GOLD STANDARD, has done nothing more than help spread this agent around the
globe. Politics and money have caused the terrible consequences to date, and the
fact that TSEs are a slow incubating death, but a death that is 100% certain for
those that are exposed and live long enough to go clinical. once clinical, there
is no recourse, to date. But, while sub-clinical, how many can one exposed human
infect? Can humans exposed to CWD and scrapie strains pass it forward as some
form of sporadic CJD in the surgical and medical arenas? why must we wait
decades and decades to prove this point, only to expose millions needlessly,
only for the sake of the industries involved? would it not have been prudent
from the beginning to just include all TSE's, and rule them out from there with
transmission studies and change policies there from, as opposed to doing just
the opposite? The science of TSE's have been nothing more than a political
circus since the beginning, and for anyone to still believe in this one strain,
one group of bovines, in one geographical location, with only one age group of
human TSE i.e. nvCJD myth, for anyone to believe this today only enhances to
spreading of these human and animal TSE's. This is exactly why we have been in
this quagmire.
The ones that believe that there is a spontaneous CJD in 85%+ of all cases
of human TSE, and the ones that do not believe that cattle can have this same
phenomenon, are two of the same, the industry, and so goes the political science
aspect of this tobacco and or asbestos scenario i.e. follow the money. I could
go into all angles of this man made nightmare, the real facts and science, for
instance, the continuing rendering technology and slow cooking with low temps
that brewed this stew up, and the fact that THE USA HAD THIS TECHNOLOGY FIRST
AND SHIPPED IT TO THE U.K. SOME 5 YEARS BEFORE THE U.S. STARTED USING THE SAME
TECHNOLOGY, to save on fuel cost. This is what supposedly amplified the TSE
agent via sheep scrapie, and spread via feed in the U.K. bovine, and other
countries exporting the tainted product. BUT most everyone ignores this fact,
and the fact that the U.S. has been recycling more TSE, from more species with
TSEs, than any other country documented, but yet, it's all spontaneous, and the
rise in sporadic CJD in the U.S. is a happenstance of bad luck ??? I
respectfully disagree. To top that all off, the infamous BSE-FIREWALL that the
USDA always brags about was nothing more than ink on paper, and I can prove
this. YOU can ignore it, but this is FACT (see source, as late as 2007, in one
recall alone, some 10,000,000 MILLION POUNDS OF BANNED MAD COW FEED WENT OUT
INTO COMMERCE TO BE FED OUT, and most was never recovered. This was banned blood
laced, meat and bone meal. 2006 was a banner year for banned mad cow protein
going into commerce in the U.S. (see source of FDA feed ban warning letter
below). I stress that the August 4, 1997 USA mad cow feed ban and this infamous
BSE firewall, was nothing more than ink on paper, it was never
enforceable.
I propose that the current diagnostic criteria for human TSEs only enhances
and helps the spreading of human TSE from the continued belief of the UKBSEnvCJD
only theory in 2009. With all the science to date refuting it, to continue to
validate this old myth, will only spread this TSE agent through a multitude of
potential routes and sources i.e. consumption, medical i.e., surgical, blood,
dental, endoscopy, optical, nutritional supplements, cosmetics etc. I propose as
with Aguzzi, Asante, Collinge, Caughey, Deslys, Dormont, Gibbs, Gajdusek,
Ironside, Manuelidis, Marsh, et al and many more, that the world of TSE
Transmissible Spongiform Encephalopathy is far from an exact science, but there
is enough proven science to date that this myth should be put to rest once and
for all, and that we move forward with a new classification for human and animal
TSE that would properly identify the infected species, the source species, and
then the route. This would further have to be broken down to strain of species
and then the route of transmission would further have to be broken down.
Accumulation and Transmission are key to the threshold from sub-clinical to
clinical disease, and key to all this, is to stop the amplification and
transmission of this agent, the spreading of, no matter what strain. In my
opinion, to continue with this myth that the U.K. strain of BSE one strain TSE
in cows, and the nv/v CJD one strain TSE humans, and the one geographical
location source i.e. U.K., and that all the rest of human TSE are just one
single strain i.e. sporadic CJD, a happenstance of bad luck that just happens
due to a twisted protein that just twisted the wrong way, IN 85%+ OF ALL HUMAN
TSEs, when to date there are 6 different phenotypes of sCJD, and growing per
Gambetti et al, and that no other animal TSE transmits to humans ??? With all
due respect to all Scientist that believe this, I beg to differ. To continue
with this masquerade will only continue to spread, expose, and kill, who knows
how many more in the years and decades to come. ONE was enough for me, My Mom,
hvCJD i.e. Heidenhain Variant CJD, DOD 12/14/97 confirmed, which is nothing more
than another mans name added to CJD, like CJD itself, Jakob and Creutzfeldt, or
Gerstmann-Straussler-Scheinker syndrome, just another CJD or human TSE, named
after another human. WE are only kidding ourselves with the current diagnostic
criteria for human and animal TSE, especially differentiating between the nvCJD
vs the sporadic CJD strains and then the GSS strains and also the FFI fatal
familial insomnia strains or the ones that mimics one or the other of those TSE?
Tissue infectivity and strain typing of the many variants of the human and
animal TSEs are paramount in all variants of all TSE. There must be a proper
classification that will differentiate between all these human TSE in order to
do this. With the CDI and other more sensitive testing coming about, I only hope
that my proposal will some day be taken seriously. ...
please see history, and the ever evolving TSE science to date ;
Saturday, June 13, 2009
Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in
the United States 2003 revisited 2009
DEEP THROAT TO TSS 2000-2001
(take these old snips of emails with how ever many grains of salt you wish.
...tss)
The most frightening thing I have read all day is the report of Gambetti's
finding of a new strain of sporadic cjd in young people...Dear God, what in the
name of all that is holy is that!!! If the US has different strains of
scrapie.....why????than the UK...then would the same mechanisms that make
different strains of scrapie here make different strains of BSE...if the
patterns are different in sheep and mice for scrapie.....could not the BSE be
different in the cattle, in the mink, in the humans.......I really think the
slides or tissues and everything from these young people with the new strain of
sporadic cjd should be put up to be analyzed by many, many experts in
cjd........bse.....scrapie Scrape the damn slide and put it into
mice.....wait.....chop up the mouse brain and and spinal cord........put into
some more mice.....dammit amplify the thing and start the damned
research.....This is NOT rocket science...we need to use what we know and get
off our butts and move....the whining about how long everything takes.....well
it takes a whole lot longer if you whine for a year and then start the
research!!! Not sure where I read this but it was a recent press release or
something like that: I thought I would fall out of my chair when I read about
how there was no worry about infectivity from a histopath slide or tissues
because they are preserved in formic acid, or formalin or formaldehyde.....for
God's sake........ Ask any pathologist in the UK what the brain tissues in the
formalin looks like after a year.......it is a big fat sponge...the agent
continues to eat the brain ......you can't make slides anymore because the agent
has never stopped........and the old slides that are stained with Hemolysin and
Eosin......they get holier and holier and degenerate and continue...what you
looked at 6 months ago is not there........Gambetti better be photographing
every damned thing he is looking at.....
Okay, you need to know. You don't need to pass it on as nothing will come
of it and there is not a damned thing anyone can do about it. Don't even hint at
it as it will be denied and laughed at.......... USDA is gonna do as little as
possible until there is actually a human case in the USA of the nvcjd........if
you want to move this thing along and shake the earth....then we gotta get the
victims families to make sure whoever is doing the autopsy is credible,
trustworthy, and a saint with the courage of Joan of Arc........I am not
kidding!!!! so, unless we get a human death from EXACTLY the same form with
EXACTLY the same histopath lesions as seen in the UK nvcjd........forget any
action........it is ALL gonna be sporadic!!!
And, if there is a case.......there is gonna be every effort to link it to
international travel, international food, etc. etc. etc. etc. etc. They will go
so far as to find out if a sex partner had ever traveled to the UK/europe, etc.
etc. .... It is gonna be a long, lonely, dangerous twisted journey to the truth.
They have all the cards, all the money, and are willing to threaten and carry
out those threats....and this may be their biggest downfall...
Thanks as always for your help. (Recently had a very startling revelation
from a rather senior person in government here..........knocked me out of my
chair........you must keep pushing. If I was a power person....I would be
demanding that there be a least a million bovine tested as soon as possible and
agressively seeking this disease. The big players are coming out of the woodwork
as there is money to be made!!! In short: "FIRE AT WILL"!!! for the very
dumb....who's "will"! "Will be the burden to bare if there is any coverup!"
again it was said years ago and it should be taken seriously....BSE will
NEVER be found in the US! As for the BSE conference call...I think you did a
great service to freedom of information and making some people feign
integrity...I find it scary to see that most of the "experts" are employed by
the federal government or are supported on the "teat" of federal funds. A scary
picture! I hope there is a confidential panel organized by the new government to
really investigate this thing.
You need to watch your back........but keep picking at them.......like a
buzzard to the bone...you just may get to the truth!!! (You probably have more
support than you know. Too many people are afraid to show you or let anyone else
know. I have heard a few things myself... you ask the questions that everyone
else is too afraid to ask.)
U.S.A. 50 STATE BSE MAD COW CONFERENCE CALL Jan. 9, 2001
Tuesday, April 21, 2015
Transmissible Spongiform Encephalopathy Advisory Committee TSEAC MEETING
SCHEDULED FOR June 1, 2015
Comment from Terry Singeltary This is a Comment on the Food and Drug
Administration (FDA) Notice: Draft Guidance for Industry on Ensuring Safety of
Animal Feed Maintained and Fed On-Farm; Availability
For related information, Open Docket Folder Docket folder icon
--------------------------------------------------------------------------------
Show agency attachment(s) Attachments View All (0)
--------------------------------------------------------------------------------
Comment View document:
Guidance for Industry Ensuring Safety of Animal Feed Maintained and Fed
On-Farm Draft Guidance FDA-2014-D-1180 Singeltary Comment
Greetings FDA et al,
I wish to comment on Guidance for Industry Ensuring Safety of Animal Feed
Maintained and Fed On-Farm Draft Guidance FDA-2014-D-1180.
Once again, I wish to kindly bring up the failed attempt of the FDA and the
ruminant to ruminant mad cow feed ban of August 4, 1997. This feed ban is still
failing today, as we speak. Even more worrisome, is the fact it is still legal
to feed cervids to cervids in the USA, in fact, the FDA only _recommends_ that
deer and elk considered to be of _high_ risk for CWD do not enter the animal
food chain, but there is NO law, its only voluntary, a recipe for a TSE prion
disaster, as we have seen with the ruminant to ruminant feed ban for cattle,
where in 2007, one decade post August 1997 mad cow feed ban, where in 2007
10,000,000 POUNDS OF BANNED BLOOD LACED MEAT AND BONE MEAL WHEN OUT INTO
COMMERCE, TO BE FED OUT. Since 2007, these BSE feed ban rules have been breached
time and time again. tons and tons of mad cow feed went out in Alabama as well,
where one of the mad cows were documented, just the year before in 2006, and in
2013 and 2014, breaches so bad (OAI) Official Action Indicated were issued.
those are like the one issued where 10 million pounds of banned blood laced meat
and bone meal were fed out.
What is the use of having a Guidance for Industry Ensuring Safety of Animal
Feed Maintained and Fed On-Farm Draft Guidance FDA-2014-D-1180, if it cannot be
enforced, as we have seen with a mandatory ruminant to ruminant feed ban?
I strenuously once again urge the FDA and its industry constituents, to
make it MANDATORY that all ruminant feed be banned to all ruminants, and this
should include all cervids as soon as possible for the following
reasons...
======
In the USA, under the Food and Drug Administrations BSE Feed Regulation (21
CFR 589.2000) most material (exceptions include milk, tallow, and gelatin) from
deer and elk is prohibited for use in feed for ruminant animals. With regards to
feed for non-ruminant animals, under FDA law, CWD positive deer may not be used
for any animal feed or feed ingredients. For elk and deer considered at high
risk for CWD, the FDA recommends that these animals do not enter the animal feed
system.
***However, this recommendation is guidance and not a requirement by law.
======
31 Jan 2015 at 20:14 GMT
*** Ruminant feed ban for cervids in the United States? ***
31 Jan 2015 at 20:14 GMT
19 May 2010 at 21:21 GMT
*** Singeltary reply ; Molecular, Biochemical and Genetic Characteristics
of BSE in Canada Singeltary reply ;
Tuesday, December 23, 2014
FDA PART 589 -- SUBSTANCES PROHIBITED FROM USE IN ANIMAL FOOD OR FEED
VIOLATIONS OFFICIAL ACTION INDICATED OAI UPDATE DECEMBER 2014 BSE TSE PRION
2013
Sunday, December 15, 2013
FDA PART 589 -- SUBSTANCES PROHIBITED FROM USE IN ANIMAL FOOD OR FEED
VIOLATIONS OFFICIAL ACTION INDICATED OAI UPDATE DECEMBER 2013 UPDATE
DOCKET-- 03D-0186 -- FDA Issues Draft Guidance on Use of Material From Deer
and Elk in Animal Feed; Availability Date: Fri, 16 May 2003 11:47:37 0500 EMC 1
Terry S. Singeltary Sr. Vol #: 1
PLEASE SEE FULL TEXT SUBMISSION ;
10,000,000+ LBS. of PROHIBITED BANNED MAD COW FEED I.E. BLOOD LACED MBM IN
COMMERCE USA 2007
Date: March 21, 2007 at 2:27 pm PST
REASON
Blood meal used to make cattle feed was recalled because it was cross-
contaminated with prohibited bovine meat and bone meal that had been
manufactured on common equipment and labeling did not bear cautionary BSE
statement.
VOLUME OF PRODUCT IN COMMERCE
42,090 lbs.
DISTRIBUTION
WI
REASON
Products manufactured from bulk feed containing blood meal that was cross
contaminated with prohibited meat and bone meal and the labeling did not bear
cautionary BSE statement.
VOLUME OF PRODUCT IN COMMERCE
9,997,976 lbs.
DISTRIBUTION
ID and NV
END OF ENFORCEMENT REPORT FOR MARCH 21, 2007
Terry S. Singeltary Sr.
*** See attached file(s) No documents available. Attachments View All (1)
Guidance for Industry Ensuring Safety of Animal Feed Maintained and Fed On-Farm
Terry Singeltary Comment View Attachment:
Sunday, April 5, 2015
*** Guidance for Industry Ensuring Safety of Animal Feed Maintained and Fed
On-Farm Draft Guidance FDA-2014-D-1180 ***
Sunday, November 23, 2014
*** Confirmed Variant Creutzfeldt-Jakob Disease (variant CJD) Case in Texas
in June 2014 confirmed as USA case NOT European ***
>>> Up until about 6 years ago, the pt worked at Tyson foods where
she worked on the assembly line, slaughtering cattle and preparing them for
packaging. She was exposed to brain and spinal cord matter when she would
euthanize the cattle. <<<
SEE MORE HERE ;
CJD TEXAS 38 YEAR OLD FEMALE WORKED SLAUGHTERING CATTLE EXPOSED TO BRAIN
AND SPINAL CORD MATTER
snip...
see ;
Sunday, February 12, 2012
National Prion Disease Pathology Surveillance Center Cases Examined1
(August 19, 2011) including Texas
Wednesday, November 09, 2011
Case report Sporadic fatal insomnia in a young woman: A diagnostic
challenge: Case Report TEXAS
HOW TO TURN A POTENTIAL MAD COW VICTIM IN THE USA, INTO A HAPPENSTANCE OF
BAD LUCK, A SPONTANEOUS MUTATION FROM NOTHING.
OR WAS IT $$$
Creutzfeldt-Jakob Disease Surveillance in Texas
Sunday, July 11, 2010
CJD or prion disease 2 CASES McLennan County Texas population 230,213 both
cases in their 40s
see the continuing rise of sporadic CJD in Texas here ;
[PDF]2015 comment singeltary.pdf - RegInfo.gov
www.reginfo.gov/public/do/DownloadDocument?documentID...0
Mar 2, 2015 - Regulations. gov - Comment regulationsgov
... Regulationsgov - Comment Page 2 of2 ... snip...please see attached pdf file, with
references of breaches in the .... The purpose ofthis notice is to solicit
comments
from the public {as ..... science based. they should do everyone a favor
and dissolve there.
Mar 2, 2015 - the atypical Nor-98 Scrapie, which has been linked to
sporadic CJD. ... the rise. with different strains mounting. victims becoming
younger. with.
WHO issues best practices for naming new human infectious diseases Note for
the media
8 May 2015 | GENEVA - WHO today called on scientists, national authorities
and the media to follow best practices in naming new human infectious diseases
to minimize unnecessary negative effects on nations, economies and people.
Terms that should be avoided in disease names include geographic locations
(e.g. Middle East Respiratory Syndrome, Spanish Flu, Rift Valley fever),
people’s names (e.g. Creutzfeldt-Jakob disease, Chagas disease), species of
animal or food (e.g. swine flu, bird flu, monkey pox), cultural, population,
industry or occupational references (e.g. legionnaires), and terms that incite
undue fear (e.g. unknown, fatal, epidemic).
Greetings WHO,
I kindly submit the following, and I will continue to call it what it is,
aka mad cow disease, and not only linked to the bovine and nvCJD to humans. mad
cow disease has now been linked to sporadic cjd, and scrapie has now been linked
to sporadic cjd, with great concern for chronic wasting disease in cerevids i.e.
cwd. or just call it what it is, Transmissible Spongiform Encephalopathy TSE
Prion disease. but I will call it for what it is, mad cow type disease, simply
because of what the stigma brings, and as long as USDA INC are still feeding
cows to cows, the OIE, and WHO continues to disregard the safety of humans there
from mad cow type disease, through the continued denial and blatant disregard
for the science to date, I refuse to play the game of denial. it is what it is,
and trying to protect the industries involved, by changing the name, it will NOT
stop the disease, only help the industry from the stigma. it is what it is, the
mad cow has been out of the barn, and there is no putting it back now. it is
what it is $$$...
kindest regards, terry
Saturday, December 13, 2014
Terry S. Singeltary Sr. Publications TSE prion disease
Diagnosis and Reporting of Creutzfeldt-Jakob Disease
Singeltary, Sr et al. JAMA.2001; 285: 733-734. Vol. 285 No. 6, February 14,
2001 JAMA
snip...
Terry S. Singeltary Sr. Bacliff, Texas USA 77518 flounder9@verizon.net
posted by Terry S. Singeltary Sr. at
10:40 AM
<< Home