Tuesday, December 04, 2012
Veterans Health Administration Information Systems as a Resource for Rare
Disorders Research: Creutzfeldt-Jakob Disease as a Paradigm
Authors: Barash, Jed A.; Desai, Rani A.; Patwa, Huned S.
Source: Military Medicine, Volume 177, Number 11, November 2012 , pp.
1343-1347(5)
Publisher: AMSUS - Association of Military Surgeons of the U.S.
ABSTRACT
Objective: To illustrate the application of Veterans Health Administration
(VHA) information systems in both clinical and epidemiologic investigations of a
rare disease, our specific aims were: (1) to determine the number and incidence
of Creutzfeldt-Jakob disease (CJD) diagnoses in the VHA from fiscal year (FY)
1997 through FY 2010 and (2) to describe the relevant clinical features
associated with those diagnoses.
Methods: The VHA Medical SAS Datasets were queried for all unique, incident
CJD diagnoses between FY 1997 and 2010. Electronic health records were then
reviewed to validate diagnoses using modified criteria.
Results: During the study period, 115 CJD diagnoses (43 definite, 27
probable, 19 possible, and 26 suspected) were identified. Annual incidence
ranged between 0.8 per million (95% CI, 0.3-1.7) in FY 2009 and 3.7 per million
(95% CI, 2.1-6.4) in FY 1997. Dementia was documented in 111 cases (96.5%) and
myoclonus in 73 (63.5%). Discharges consistent with CJD were noted in 31 of 78
patients (39.7%) with documented electroencephalography.
Conclusions: For certain rare diseases, VHA information systems can be used
to assemble a substantive case series for clinical study. However, the VHA's
distinctive demographic characteristics and population dynamics may limit the
external validity of epidemiologic investigations.
Document Type: Research article
Publication date: 2012-11-01
> and 3.7 per million (95% CI, 2.1-6.4) in FY 1997.
interesting...disturbing too, but just another happenstance of bad luck,
another coincidence, etc., etc, zaaaaa ...tss
Friday, August 22, 2008
Creutzfeldt Jakob Disease and Veterans and how they are treated at death
Sunday, December 2, 2012
CANADA 19 cases of mad cow disease SCENARIO 4: ‘WE HAD OUR CHANCE AND WE
BLEW IT’
Friday, November 23, 2012
sporadic Creutzfeldt-Jakob Disease update As at 5th November 2012 UK, USA,
AND CANADA
Tuesday, November 6, 2012
Transmission of New Bovine Prion to Mice, Atypical Scrapie, BSE, and
Sporadic CJD, November-December 2012 update
Sunday, December 2, 2012
CANADA 19 cases of mad cow disease SCENARIO 4: ‘WE HAD OUR CHANCE AND WE
BLEW IT’
Wednesday, May 16, 2012
Alzheimer’s disease and Transmissible Spongiform Encephalopathy prion
disease, Iatrogenic, what if ?
Proposal ID: 29403
Monday, August 20, 2012
CASE REPORTS CREUTZFELDT-JAKOB DISEASE: AN UNDER-RECOGNIZED CAUSE OF
DEMENTIA
see the Duke, Pa, Yale, and Mexican study here, showing the misdiagnosis of
CJD TSE prion disease as Alzheimers ;
Thursday, October 25, 2012
Current limitations about the cleaning of luminal endoscopes and TSE prion
risk factors there from
Article in Press
Saturday, October 6, 2012
TRANSMISSION, DIFFERENTIATION, AND PATHOBIOLOGY OF TRANSMISSIBLE SPONGIFORM
ENCEPHALOPATHIES 2011 Annual Report
Wednesday, September 19, 2012
Prion reduction of red-blood-cells
INTERNATIONAL FORUM
Monday, September 17, 2012
Rapid Transepithelial Transport of Prions Following Inhalation
Monday, September 17, 2012
Rapid Transepithelial Transport of Prions Following Inhalation
Enforcement Report - Week of August 29, 2012
Class II, Blood products, collected from a donor who was at risk for
variant Creutzfeldt-Jakob Disease (vCJD), were distributed. Belle Bonfils
Memorial Blood ...
Thursday, August 16, 2012
Blood products, collected from a donor who was at risk for variant
Creutzfeldt-Jakob disease ( vCJD) USA JUNE, JULY, AUGUST 2012
Tuesday, July 31, 2012
11 patients may have been exposed to fatal disease Creutzfeldt-Jakob
Disease CJD Greenville Memorial Hospital
Semper Fi
tss
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