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Tuesday, August 23, 2022

Creutzfeldt-Jakob Disease Incidence, South Korea, 2001–2019

Volume 28, Number 9—September 2022

Dispatch

Creutzfeldt-Jakob Disease Incidence, South Korea, 2001–2019

Yong-Chan Kim and Byung-Hoon JeongComments to Author 

Author affiliation: Jeonbuk National University, Jeonju, South Korea

Abstract

We found increasing trends of Creutzfeldt-Jakob disease (CJD) cases and annual incidence in South Korea during 2001–2019. We noted relatively low (5.7%) distribution of familial CJD. An unusually high percentage (≈1%) of patients were in the 30–39 age group, which should prompt a preemptive CJD control system.

Prion diseases are fatal, irreversible, and transmissible brain proteinopathies caused by abnormal aggregated prion protein (PrPSc) converted from normal prion protein (PrPC), which is encoded by the prion protein gene (PRNP) (1–3). The major type of human prion disease is Creutzfeldt-Jakob disease (CJD), and several countries have reported increasing trends in CJD cases and incidence (4).

CJD is subdivided into 3 types: sporadic, familial, and iatrogenic (5–7). The most common type is sporadic CJD, which accounts for >85% of all CJD cases. Familial CJD accounts for 10%–15% of all cases and is caused by germline mutations of the human PRNP gene, including D178N-M129V, V180I, E200K, V203I, and M232R. Iatrogenic CJD accounts for <1% of all CJD cases and includes variant CJD, which is caused by ingestion of beef products from bovine spongiform encephalopathy–affected cattle (7–9).

In South Korea, the Korea Centers for Disease Control and Prevention (KCDC) has operated the CJD surveillance system and issued epidemiologic reports since 2001. In addition, except for variant CJD, the surveillance system has reported all 3 types of CJD. Furthermore, CJD has been reported annually and has exhibited increasing trends in case numbers. However, no long-term estimation of the various characteristics of CJD patients, including onset age, sex, germline mutations of familial CJD, or overall CJD incidence are available for South Korea. We conducted a study on CJD cases in South Korea from 2001–2019 to assess case count and incidence trends.

The Study

We collected data on CJD patients from Statistics Korea (KOSTAT) (https://kostat.go.krExternal Link) and epidemiologic reports issued by the KCDC (https://www.kdca.go.krExternal Link). We analyzed the characteristics of CJD patients in South Korea. In addition, we obtained the global incidence of sporadic CJD from previous studies and compared these with the incidence in South Korea (4).

CJD diagnosis was performed according to guidelines from the World Health Organization in South Korea (10). During 2001–November 2010, CJD was controlled through a sample monitoring system centered in medical institutions in the country and KCDC collected the CJD-related data. Beginning December 2010, CJD was designated as a statutory infectious disease, and KCDC conducts a complete epidemiologic investigation and monitors suspected patients. CJD death rates in South Korea have not been available.

The number of possible, probable, and definite CJD diagnoses was not available during 2001–2015. Among all cases during 2016–2019, KCDC reported 6 (3.2%) possible CJD cases, 179 (95.2%) probable cases, and 3 (1.6%) definite cases. Genetic testing was performed on all patients with diagnosed CJD.

We obtained population data stratified by age, region, sex, and year from KOSTAT. We used χ2 test to determine statistically significant differences and performed calculations in SAS version 9.4 (SAS Institute Inc., https://www.sas.comExternal Link).

Annual incidence of Creutzfeldt-Jakob disease, South Korea, 2001–2019. A) Total number of reported cases per year and sex. B) Annual incidence per million population. 

Figure 1. Annual incidence of Creutzfeldt-Jakob disease, South Korea, 2001–2019. A) Total number of reported cases per year and sex. B) Annual incidence per million population.

During 2001–2019, a total of 579 CJD cases were reported in South Korea (Table). Of note, the annual number of cases and CJD incidence in South Korea exhibited an upward trend (Figure 1, Table). Among 579 cases, 545 (94.13%) were sporadic, 33 (5.7%) were familial, and 1 (0.17%) was iatrogenic. Variant CJD was not reported in Korea during 2001–2019 (Table). During 2008–2019, a total of 31 familial CJD cases were reported, as were 5 types of germline mutations of the PRNP gene, including D178N-M129V, V180I, E200K, V203I and M232R (Appendix Table 1, Figure 1).

During 2011–2019, a total of 394 cases of CJD were reported in South Korea; 162 (41.12%) among persons >70 years of age, 129 (32.74%) among persons 60–69 years of age, 75 (19.04%) among persons 50–59 years of age, 23 (5.84%) among persons 40–49 years of age, and 5 (1.27%) among persons 30–39 years of age (AppendixTable 2, Figure 2). Of note, the distribution of CJD cases by age in South Korea was significantly different in 2011 compared with 2011–2019 (p<0.05). In particular, the distribution of CJD in the 40–49 year age group in 2011 (17.24%) was ≈2.9 times higher than that of the 40–49 age group during 2011–2019 (5.84%).

Creutzfeldt-Jakob disease (CJD) incidence, South Korea and globally, 2001–2019. A) Number of cases and incidence per million persons in cities and provinces of South Korea, including probable, possible, and definite CJD diagnoses. B) Global number of sporadic CJD cases and incidence per million population by country (4). Sporadic CJD incidence for South Korea is from this study. Figure 2. Creutzfeldt-Jakob disease (CJD) incidence, South Korea and globally, 2001–2019. A) Number of cases and incidence per million persons in cities and provinces of South Korea, including probable, possible, and definite...

Overall, Gyeonggi Province had the highest number of CJD cases (88, 22.34%), along with the cities of Seoul (83 cases, 21.07%), Busan (25 cases, 6.35%), and Daegu (25 cases, 6.35%). Sejong (2 cases, 0.51%) and Jeju (2 cases, 0.51%) had the fewest CJD cases, and Ulsan (7 cases, 1.78%) and Gwanju (8 cases, 2.03%) also had fewer cases than other cities (Appendix Table 3). Chungnam Province had the highest CJD incidence (1.21 cases per million population), along with the cities of Sejong (1.19 cases per million population) and Daegu (1.13 cases per million population). The city of Jeju had the lowest CJD incidence (0.37 cases per million population), and Gwangju (0.59 cases per million population) and Incheon (0.62 cases per million population) also had low incidence (Figure 2, panel A).

We compared the incidence of sporadic CJD in South Korea with the global incidence. Switzerland had the highest incidence (1.73 cases per million population), but incidence was also high in France (1.6 cases per million population) and Austria (1.52 cases per million population). Estonia had the lowest incidence of sporadic CJD at 0.32 cases per million population. By comparison, incidence of sporadic CJD in South Korea was extremely low, 0.54 cases per million population (Figure 2, panel B).

Conclusions

In this study, we found increasing trends in CJD rates in South Korea during 2001–2019. These increasing trends might be the result of advanced diagnostic technology and capacity, more neurologic specialists, an increase in the average age of the population, or a combination of these factors. In addition, designation of CJD as a statutory infectious disease might have affected increased reporting. Nonetheless, further research could investigate the CJD incidence trend through the country’s high-level surveillance system.

In addition, we observed that ≈1% of CJD patients in South Korea were in the 30–39-year age group (Appendix Figure 2). Because the average age of onset of familial CJD is over 50, younger CJD patients in the 30–39-year age group are extremely unusual (11,12). However, the exact subtypes of CJD (sporadic or variant) for each CJD patient in this age group were not available. Previous studies have reported variant CJD occurring at a relatively younger age than familial and sporadic CJD (7–9). Thus, further in-depth investigation of the subtypes of CJD among younger age groups is essential to determine causes of CJD in this age group and devise prevention strategies.

In conclusion, we identified increasing trends of CJD cases and incidence in South Korea during 2001–2019. We investigated CJD cases by subtype and found a relatively low (5.7%) distribution of familial CJD. Of note, sporadic CJD incidence was only 0.54 cases per million persons. In addition, we investigated the distribution of CJD patients by sex, age group, and region and found the highest incidence in the Chungnam region. A comprehensive long-term investigation could shed light on the characteristics of CJD in South Korea and help KCDC construct a preemptive control system.

Dr. Kim is research professor in the Korea Zoonosis Research Institute, Jeonbuk National University, Jeonbuk, South Korea. His research interests include prion diseases.

Dr. Jeong is associate professor in the Korea Zoonosis Research Institute, Jeonbuk National University. His research interests include prion diseases.

Acknowledgment

This work was supported by the National Research Foundation of Korea (NRF) through a grant funded by the Korea government (grant no. 2021R1A2C1013213); NRF grant NRF-2019-Fostering Core Leaders of the Future Basic Science Program/Global Ph.D. Fellowship Program); and the Basic Science Research Program through NRF funded by the Ministry of Education (grant nos. 2017R1A6A1A03015876, 2021R1A6A3A010864, 2022R1C1C2004792). Y.-C.K. was supported by the BK21 Plus Program in the Department of Bioactive Material Sciences, Jeonbuk National University.

References


KOREA CWD UPDATE 2022

FRIDAY, MARCH 18, 2022 

Korea Chronic Wasting Disease CWD TSE PrP Update Increase of Positive Cases and Polymorphisms of the prion-related protein gene 

IN 235 elks, 22 elks (9.4%) were infected with CWD.

IN 257 red deer, 78 red deer (30.4%) were infected with CWD.

IN 150 sika deer, 16 sika deer (10.7%) were infected with CWD.


SUNDAY, JULY 14, 2019 

Korea Chronic Wasting Disease CWD TSE Prion additional cases were observed in red deer, sika deer, and their crossbred deer in 2010 and 2016, beyond that, anyone's guess


HISTORY

USDA VS KOREA typical or atypical BSe

FRIDAY, MAY 9, 2008 

USDA VS KOREA typical or atypical BSe

Honorable people of Korea,

a kind and warm greetings from Texas.

i cannot sit here and allow my government to lie to the korean people. i have been following the issue of Transmissible Spongiform Encephalopathy for over a decade, since the death of my mother to the Heidenhain Variant of Creutzfeldt Jakob Disease, confirmed. i have followed this on a daily basis since 12-14-97. there is so much i want to tell you, that the USDA and the FDA are not telling you.

i almost got to see your beautiful country, but in the last minute, my trip was cancelled. i was asked to come speak a year or so ago ;

Name: Terry S. Singeltary Sr. 

Date: Jan 26, 2007 

Dear Terry S. Singeltary Sr. 

My name in Seoungwon Lee and I work for National Assemblywoman (MP) Sang-Jeong Sim, in South Korea. Below is a message from Mr. Kwon. Please get back to us regarding the letter. Thank you. Seoungwon Lee Legislative Assistant National Assembly Republic of Korea

Dear Terry S. Singeltary Sr.

Greetings from Korea.

I have learned about what you and your family have been through a internet. Being the father of a small family, I can only imagine the sense of loss that you and your family still must feel regarding your mother.

Through the internet, many people here in Korea have learnt about the story of your family and it has created a great deal of concern. Your experience had particular relevance for the citizens here, for the Korean government, in connection to the free trade agreement it is negotiating with the United States, is about to restart the sale of the unsafe American beef to the general public.

The Korean government has already imported the first load American beef and is currently going through the inspection period. There has been a great deal of controversy regarding the safety of these products, and a precipitous increase in public interest regarding the causes and symptoms of vCJD.

It is in this context that we are preparing a session together with National Assembly members and relevant NGOs to hear from those who have had direct experience with the human variant of BSE. We are very interested in hearing about the symptoms that your mother showed, your views on the response from the US government to the many deaths that resulted from this disease, the reaction from the general public, and any other area that you would wish to speak about. There would also be experts and academics in the area to speak at the session as well. We believe that it would greatly contribute to raising awareness about the issue, as well as help politicians and civic activists to consider the repercussions of the beef import issue.

We would like to request your help in this regard. We are planning for the session to be held in Seoul on the 23rd of this November. We would very much like to have you present in order to help prevent such tragic incidents from happening in Korea. We would, of course, pay for the trip and accommodations for the duration of your stay. If you were to participate, we could also meet with members from the agricultural committee of the National Assembly and from other related organizations to urge more interest to the issue.

Please do not hesitate to offer suggestions or ask us any questions that you might have. We look forward to a positive response and to meeting you in Seoul.

Thank you. Sincerely, Sim Sang-Jeong Head of the Democratic Labor Party Parliamentary Committee on the Korea-US FTA Member of the National Assembly Republic of Korea






snip...see;

FRIDAY, SEPTEMBER 29, 2017 

10 years later, Kim Min-sun now Kim Gyu-ri, an internet post haunts actress, U.S. beef imports and Mad Cow Disease


Terry S. Singeltary Sr.