From: Terry S. Singeltary Sr.
Sent: Monday, December 02, 2013 9:00 PM
To: BSE-L BSE-L
Cc: HCinfo@parliament.uk ; standardscommissioner@parliament.uk
; hudsonk@parliament.uk ; prawerj@parliament.uk ; woodhj@parliament.uk ; gentd@parliament.uk ; wainwrightp@parliament.uk ; enquiries@swt.org.uk ; admin@jmt.org ; info@johnmuiraward.org ; nicky.mcclure@jmt.org ; CJD-L ; CJDVOICE
CJDVOICE ; bloodcjd bloodcjd ; prbohoc@parliament.uk ; holsupport@parliament.uk
Subject: A parliamentary inquiry has been launched today into the
safety of blood, tissue and organ screening following fears that vCJD – the
human form of ‘mad cow’ disease – may be being spread by medical
procedures
Greetings
Honorable Members of the U.K. Parliament, House of Commons, et al,
I tried to
comment, but the comment page was not working electronically, so I kindly wish
to submit the following please.
IN REPLY TO
;
03 December
2013
A parliamentary inquiry has been launched today
into the safety of blood, tissue and organ screening following fears that vCJD –
the human form of ‘mad cow’ disease – may be being spread by medical procedures.
- Inquiry: Blood, tissue and organ screening
- Inquiry: variant Creutzfeldt-Jakob Disease (vCJD)
- Science and Technology Committee
Leading scientific experts told the Committee that the infectious agent responsible for vCJD—a type of abnormal protein called a prion—could be present in the UK blood supply and that blood and organ donation could therefore represent a major source of future vCJD infections.
Following this session, the Science and Technology Committee has agreed to hold an inquiry into blood, tissue and organ screening. Chair of the Committee Andrew Miller MP stated:
“Variant Creutzfeldt-Jakob Disease is a terrible condition and we were extremely concerned to hear evidence that this incurable disease still poses a significant risk to public health.
Although the risk of developing the disease as a result of eating contaminated beef was long ago eliminated, it is possible that the infection could still be unwittingly spread through medical procedures. We were told that this may happen through failure to properly clean medical instruments, or, even more worryingly, through widespread contamination of the blood and organ supply.
We want to explore whether the Government is taking this threat as seriously as it should be. Our new inquiry will investigate these issues in more detail and consider ways in which the UK can protect its vital supply of donated blood, tissues and organs.”
The new inquiry follows on from a one-off evidence session that took place on Wednesday 27 November.
Terms of Reference
The Committee is seeking written submissions on the following matters:- Are UK policies governing who can donate blood and blood products, tissues and organs sufficiently evidence-based? Is NHS Blood and Transplant overly restrictive about who can donate, or should greater precautions be taken to further reduce risk?
- Is the Government and its scientific advisory structure sufficiently responsive to the threat posed by emerging diseases being transmitted through blood and blood products, tissues and organs?
- Has the threat of ongoing transmission of vCJD through the blood and blood product supply been adequately mitigated?
- What are the strengths and weaknesses of NHS Blood and Transplant’s strategy, “Taking Organ Transplantation to 2020”? What further changes could be made to safely increase the supply of blood and blood products, tissues and organs?
- What lessons could be learnt from the screening and donation practices of other countries?
Submitting written evidence
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Each submission should:
- be no more than 3,000 words in length
- be in Word format with as little use of logos as possible
- have numbered paragraphs
- include a declaration of interests.
The Clerk
Science and Technology Committee
House of Commons
14 Tothill Street
London
SW1H 9NB
Please note that:
- Material already published elsewhere should not form the basis of a submission, but may be referred to within a proposed memorandum, in which case a hard copy of the published work should be included.
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Further information
- Submitting evidence to Select Committees
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http://www.parliament.uk/business/committees/committees-a-z/commons-select/science-and-technology-committee/inquiries/parliament-2010/blood-tissue-and-organ-screening/
Written submissions to the inquiry should be submitted online:
http://www.parliament.uk/business/committees/committees-a-z/commons-select/science-and-technology-committee/inquiries/parliament-2010/blood-tissue-and-organ-screening/commons-written-submission-form/
??? DID NOT WORK FOR ME ???
House of Commons
Science and Technology CommitteeOral evidence: variant Creutzfeldt-Jakob
Disease (vCJD), HC
846
Wednesday 27 November 2013
Ordered by the House of Commons to be published on 27 November 2013.
Written evidence from witnesses:
– Professor James Ironside
– Dr Roland Salmon
– Professor John Collinge
Watch the meeting
Members present: Andrew Miller (Chair); Jim Dowd; Mr David Heath; Stephen
Metcalfe;
Pamela Nash; Sarah Newton; Graham Stringer; David Tredinnick
Questions 1-46
Witnesses
Wednesday 27 November 2013, Thatcher Room, Portcullis HouseAt 9.05 am
- Dr Roland Salmon, Joint Chair, Advisory Committee on Dangerous Pathogens TSE Sub Group
- Professor James Ironside, Professor of Clinical Neuropathology, National CJD Research and Surveillance Unit, University of Edinburgh
- Professor John Collinge, Professor of Neurology at the UCL Institute of Neurology and Director of the MRC Prion Unit
Andrew Miller MP, Chair of the Science and Technology Committee, said:
“More than twenty years on from the BSE crisis, studies have suggested that thousands of people may still carry the infectious agent thought to cause variant Creutzfeldt-Jakob Disease—the human form of “mad cow disease”.
“Although these people may never go on to develop symptoms of vCJD, important questions remain to be asked about the potential risk posed by this terrible condition and what the Government should be doing to reduce the spread of infection.”
Further information
Image: Parliamentary copyright27 Nov 2013 - variant Creutzfeldt-Jakob Disease (vCJD) - oral evidence | PDF version (
309 KB)
Published 02 Dec
2013
Evidence given by Professor James Ironside,
Professor of Clinical Neuropathology, National CJD Research and Surveillance
Unit, University of Edinburgh, Dr Roland Salmon, Joint Chair, Advisory Committee
on Dangerous Pathogens TSE Sub Group, and Professor John Collinge, Professor of
Neurology, UCL Institute of Neurology and Director of the MRC Prion
Unit.
NHS failed to sterilise surgical
instruments contaminated with 'mad cow' disease
Regular sterilisation procedure wasn't suitable for the task, says leading specialist Steve Connor Author Biography Science Editor Wednesday 27 November 2013
The NHS has failed to use an effective method of sterilising surgical instruments contaminated with the human form of “mad cow” disease because it did not fit in with its established washing procedures, a leading specialist in variant Creutzfeldt-Jakob disease (vCJD) claimed yesterday.
The result is that hundreds of people have had their lives blighted by surgery performed with instruments possibly contaminated the prion protein responsible for vCJD said Professor John Collinge, director of the Medical Research Council’s Prion Unit at University College London.
Professor Collinge led one of a number of research groups that came up with novel ways of destroying the lethal prion protein, which sticks to the stainless steel of surgical instruments like superglue and can survive the high temperatures of hospital autoclaves.
However, in evidence to the House of Commons science and technology committee, Professor Collinge said that he was astonished and disappointed that the Department of Health and the NHS failed to adopt any of the suggestions for decontaminating surgical instruments.
“The solution we developed was a combination of enzymes and detergents, if you like a sort of bespoke biological washing powder which very effectively prion-decontaminated metal surfaces,” Professor Collinge said.
It was one of several decontamination procedures developed by a number of research groups sponsored by the health department over a decade ago to find ways of making surgical instruments safe, he said.
“Neither this nor the other products that were available – I think there were three – have ever been taken up by the NHS. They simply haven’t been used. These issues have been bounced around various committees to my and other peoples’ great frustration,” Professor Collinge said.
“It’s perhaps not surprising given that the NHS is notoriously resistant to change and to introducing new methodologies,” he said.
“Absolutely nothing has happened despite all this research and all this effort. Currently several hundred people have been notified that they have been exposed to [potentially contaminated] surgical instruments,” he told the committee.
“We’re blighting these peoples’ lives and all this has been avoidable for some years by applying this research. I find it quite extraordinary that the system just does not work,” he said.
“They’ve had to be notified that they’ve had a significant exposure to prions because they are expected to take precautions. They are not allowed to be blood donors and if they go on to have surgery they have to notify the surgeons that they are high risk individuals.
“Needless to say this has a major effect on their lives and needless to say it makes me very angry because all of this was avoidable,” he added.
DuPont, an American chemicals company, worked out a way of manufacturing Professor Collinge’s product as a 50C pre-soak for surgical instruments, but because this would involve changing the standard procedures for how medical devices were sterilised, NHS hospitals refused to adopt it, Professor Collinge claimed.
“What we had developed was seen to be inconvenient…The NHS didn’t buy a single unit of the product so was it surprising that the manufacturer just walked away?” he said.
“It was extraordinary [that] it was discussed in I don’t know how many committees and subcommittees when patients are being put in this position and having their lives blighted. It’s disgraceful,” he told the committee.
About 200 hospital patients have been told that they have been exposed to the vCJD prion through instruments that were used on other patients who subsequently died of the brain disease. Three out of the 177 people in the UK who have died of vCJD received contaminated blood, and the rest are assumed to have been infected by meat or meat products contaminated with bovine spongiform encephalopathy (BSE).
A spokesman for the Department of Health said that Professor Collinge’s research group has received £18m for various research projects and that DuPont’s prion inactivation product has been reviewed twice by Public Health England’s Rapid Review Panel, which established “gaps” in DuPont’s application.
Roland Salmon, the joint chairman of the government’s advisory sub-committee on dangerous pathogens, defended the Department of Health’s stance on introducing new ways of sterilising surgical instruments.
“I don’t think it’s fair on the department [of health] to say that nothing was done…they did institute a number of improvements,” Dr Salmon said.
“It’s perfectly true they haven’t introduced specific products…the barrier had been I’ve told with having a product composed in such a way that it can be introduced into what is an industrialised process in a cycle,” he said.
How vCJD can be contracted
Almost all of the 177 cases of vCJD – the human form of “mad cow” disease – have been contracted through eating contaminated meat or meat products before the introduction of controls to limit the spread of bovine spongiform encephalopathy (BSE) from cattle to people.
Three of these deaths, however, are believed to have resulted from blood donors infected with vCJD, but showing no clinical symptoms. There is one further case of a person who died of something else but who was shown at post-mortem to be infected following a blood transfusion.
There are fears of secondary infections from asymptomatic carriers in the population. Latest estimates suggest that up to one in 2,000 people in Britain could be carriers of vCJD.
Because the prion protein responsible for vCJD is found in a wide range of tissues, such as spleen, tonsils and appendix, the fear is that asymptomatic carriers may spread the infection to others through contaminated surgical instruments and blood donations.
http://www.independent.co.uk/news/science/nhs-failed-to-sterilise-surgical-instruments-contaminated-with-mad-cow-disease-8967763.html
Regular sterilisation procedure wasn't suitable for the task, says leading specialist Steve Connor Author Biography Science Editor Wednesday 27 November 2013
The NHS has failed to use an effective method of sterilising surgical instruments contaminated with the human form of “mad cow” disease because it did not fit in with its established washing procedures, a leading specialist in variant Creutzfeldt-Jakob disease (vCJD) claimed yesterday.
The result is that hundreds of people have had their lives blighted by surgery performed with instruments possibly contaminated the prion protein responsible for vCJD said Professor John Collinge, director of the Medical Research Council’s Prion Unit at University College London.
Professor Collinge led one of a number of research groups that came up with novel ways of destroying the lethal prion protein, which sticks to the stainless steel of surgical instruments like superglue and can survive the high temperatures of hospital autoclaves.
However, in evidence to the House of Commons science and technology committee, Professor Collinge said that he was astonished and disappointed that the Department of Health and the NHS failed to adopt any of the suggestions for decontaminating surgical instruments.
“The solution we developed was a combination of enzymes and detergents, if you like a sort of bespoke biological washing powder which very effectively prion-decontaminated metal surfaces,” Professor Collinge said.
It was one of several decontamination procedures developed by a number of research groups sponsored by the health department over a decade ago to find ways of making surgical instruments safe, he said.
“Neither this nor the other products that were available – I think there were three – have ever been taken up by the NHS. They simply haven’t been used. These issues have been bounced around various committees to my and other peoples’ great frustration,” Professor Collinge said.
“It’s perhaps not surprising given that the NHS is notoriously resistant to change and to introducing new methodologies,” he said.
“Absolutely nothing has happened despite all this research and all this effort. Currently several hundred people have been notified that they have been exposed to [potentially contaminated] surgical instruments,” he told the committee.
“We’re blighting these peoples’ lives and all this has been avoidable for some years by applying this research. I find it quite extraordinary that the system just does not work,” he said.
“They’ve had to be notified that they’ve had a significant exposure to prions because they are expected to take precautions. They are not allowed to be blood donors and if they go on to have surgery they have to notify the surgeons that they are high risk individuals.
“Needless to say this has a major effect on their lives and needless to say it makes me very angry because all of this was avoidable,” he added.
DuPont, an American chemicals company, worked out a way of manufacturing Professor Collinge’s product as a 50C pre-soak for surgical instruments, but because this would involve changing the standard procedures for how medical devices were sterilised, NHS hospitals refused to adopt it, Professor Collinge claimed.
“What we had developed was seen to be inconvenient…The NHS didn’t buy a single unit of the product so was it surprising that the manufacturer just walked away?” he said.
“It was extraordinary [that] it was discussed in I don’t know how many committees and subcommittees when patients are being put in this position and having their lives blighted. It’s disgraceful,” he told the committee.
About 200 hospital patients have been told that they have been exposed to the vCJD prion through instruments that were used on other patients who subsequently died of the brain disease. Three out of the 177 people in the UK who have died of vCJD received contaminated blood, and the rest are assumed to have been infected by meat or meat products contaminated with bovine spongiform encephalopathy (BSE).
A spokesman for the Department of Health said that Professor Collinge’s research group has received £18m for various research projects and that DuPont’s prion inactivation product has been reviewed twice by Public Health England’s Rapid Review Panel, which established “gaps” in DuPont’s application.
Roland Salmon, the joint chairman of the government’s advisory sub-committee on dangerous pathogens, defended the Department of Health’s stance on introducing new ways of sterilising surgical instruments.
“I don’t think it’s fair on the department [of health] to say that nothing was done…they did institute a number of improvements,” Dr Salmon said.
“It’s perfectly true they haven’t introduced specific products…the barrier had been I’ve told with having a product composed in such a way that it can be introduced into what is an industrialised process in a cycle,” he said.
How vCJD can be contracted
Almost all of the 177 cases of vCJD – the human form of “mad cow” disease – have been contracted through eating contaminated meat or meat products before the introduction of controls to limit the spread of bovine spongiform encephalopathy (BSE) from cattle to people.
Three of these deaths, however, are believed to have resulted from blood donors infected with vCJD, but showing no clinical symptoms. There is one further case of a person who died of something else but who was shown at post-mortem to be infected following a blood transfusion.
There are fears of secondary infections from asymptomatic carriers in the population. Latest estimates suggest that up to one in 2,000 people in Britain could be carriers of vCJD.
Because the prion protein responsible for vCJD is found in a wide range of tissues, such as spleen, tonsils and appendix, the fear is that asymptomatic carriers may spread the infection to others through contaminated surgical instruments and blood donations.
http://www.independent.co.uk/news/science/nhs-failed-to-sterilise-surgical-instruments-contaminated-with-mad-cow-disease-8967763.html
I kindly submit the following ;
Greetings again,
AS usual, the media and the medical community missing the bigger picture. this incident also risk the medical iatrogenic transmission of ALL TSE PRION DISEASE, not just the UKBSEnvCJD only myth.
IN fact, there has never been an iatrogenic CJD event with nvCJD, except the 5 documented iatrogenic events with blood and nvCJD.
all other medical, surgical transmission was all with sporadic CJD, which is all iatrogenic CJD is, is sporadic CJD, until the the iatrogenic event is documented, proven, and then placed in the academic domain.
sadly, in my honest opinion, this will just be another BSE
human TSE mad cow whitewash, like the BSE Inquiry, and the UKBSEnvCJD _only_
theory/myth was.
I kept up with the BSE Inquiry _daily_, even made a submission in 1998 to the BSE Inquiry about Nutritional Supplements and SRMs, and I see this having no chance of being any different $$$
I pray that I am wrong. I am waiting for that day in the USA and North America mad cow bse cjd inquiry, but that day will never come$$$
I apologize if I sound angry, I suppose I still am. ...
with kindest regards, terry
I kept up with the BSE Inquiry _daily_, even made a submission in 1998 to the BSE Inquiry about Nutritional Supplements and SRMs, and I see this having no chance of being any different $$$
I pray that I am wrong. I am waiting for that day in the USA and North America mad cow bse cjd inquiry, but that day will never come$$$
I apologize if I sound angry, I suppose I still am. ...
with kindest regards, terry
kind regards,
terry
Wednesday, November 27, 2013
NHS failed to sterilise surgical instruments contaminated with 'mad cow' disease
http://transmissiblespongiformencephalopathy.blogspot.com/2013/11/nhs-failed-to-sterilise-surgical.html
NHS failed to sterilise surgical instruments contaminated with 'mad cow' disease
http://transmissiblespongiformencephalopathy.blogspot.com/2013/11/nhs-failed-to-sterilise-surgical.html
see my history of the BSE Inquiry whitewash at
bottom...for anyone still interested...tss
IATROGENIC
all iatrogenic cjd is, is sporadic CJD, until route and source of the iatrogenic event that took place, is detected, documented, placed in the academic domain as fact, and recorded, which happens very seldom due to a lot of factors, besides the incubation period, and that be mainly industry. kind of like asbestos and tobacco and the industry there from, they knew in the early 1900’s that they both were killing, and they both had long incubation, and somebody chose not to do anything about if for decades and decades. kind of like what we have here with the TSE prion disease. $$$
> In 12 of 15 hospitals with neurosurgical incidents, a decision was made to notify patients of their potential exposure.
SO, X number of patients, from 3 hospitals, where
''exposure to potentially CJD-contaminated instruments ''
took place on these patients, the final decision NOT to tell those folks about the potential exposure to the CJD TSE prion
insane, thus, the TSE prion agent continues to spread. ...please see further comments here ;
Saturday, November 16, 2013
Management of neurosurgical instruments and patients exposed to creutzfeldt-jakob disease 2013 December
Infect Control Hosp Epidemiol.
http://creutzfeldt-jakob-disease.blogspot.com/2013/11/management-of-neurosurgical-instruments.html
Management of neurosurgical instruments and patients exposed to creutzfeldt-jakob disease 2013 December
Infect Control Hosp Epidemiol.
http://creutzfeldt-jakob-disease.blogspot.com/2013/11/management-of-neurosurgical-instruments.html
Thursday, November 14, 2013
Prion diseases in humans: Oral and dental implications
http://transmissiblespongiformencephalopathy.blogspot.com/2013/11/prion-diseases-in-humans-oral-and.html
Saturday, November 2, 2013
Recommendation of the Swiss Expert Committee for Biosafety on the classification of activities using prion genes and prion protein January 2013
http://transmissiblespongiformencephalopathy.blogspot.com/2013/11/recommendation-of-swiss-expert.html
Prion diseases in humans: Oral and dental implications
http://transmissiblespongiformencephalopathy.blogspot.com/2013/11/prion-diseases-in-humans-oral-and.html
Saturday, November 2, 2013
Recommendation of the Swiss Expert Committee for Biosafety on the classification of activities using prion genes and prion protein January 2013
http://transmissiblespongiformencephalopathy.blogspot.com/2013/11/recommendation-of-swiss-expert.html
Friday, November 29, 2013
Identification of Misfolded Proteins in Body Fluids for the Diagnosis of Prion Diseases
International Journal of Cell Biology
http://transmissiblespongiformencephalopathy.blogspot.com/2013/11/identification-of-misfolded-proteins-in.html
CJD Mark Tami: To ask the Secretary of State
for Health (1) what steps his Department has put in place to monitor the number
of people who carry the abnormal prion protein which causes variant
Creutzfeldt-Jakob disease; [174628]
(2) when he plans that screening of the abnormal prion protein which causes variant Creutzfeldt-Jakob disease will be introduced; [174631]
(3) what assessment he has made of the number of people who carry the abnormal prion protein which causes variant Creutzfeldt-Jakob disease. [174633]
12 Nov 2013 : Column 615W
Jane Ellison: The presence of abnormal prion protein is currently taken as a marker for asymptomatic carriage of variant Creutzfeldt-Jakob disease or for symptomatic infection. A recent study to assess carriage by looking at stored appendix tissue samples, first published in the Health Protection Report in August 2012, found abnormal prion protein in 16 appendices out of 32,441 samples. This suggests a prevalence of about 1 in 2,000.
There is no monitoring of people who may carry the abnormal prion protein; all appendix prevalence studies are anonymised.
No routine screening can yet take place as there are no suitable validated screening tests for abnormal prion protein available. The Department, together with the United Kingdom Blood Services, continues to monitor, scientific research and development in this area.
http://www.publications.parliament.uk/pa/cm201314/cmhansrd/cm131112/text/131112w0004.htm#13111283000003
(2) when he plans that screening of the abnormal prion protein which causes variant Creutzfeldt-Jakob disease will be introduced; [174631]
(3) what assessment he has made of the number of people who carry the abnormal prion protein which causes variant Creutzfeldt-Jakob disease. [174633]
12 Nov 2013 : Column 615W
Jane Ellison: The presence of abnormal prion protein is currently taken as a marker for asymptomatic carriage of variant Creutzfeldt-Jakob disease or for symptomatic infection. A recent study to assess carriage by looking at stored appendix tissue samples, first published in the Health Protection Report in August 2012, found abnormal prion protein in 16 appendices out of 32,441 samples. This suggests a prevalence of about 1 in 2,000.
There is no monitoring of people who may carry the abnormal prion protein; all appendix prevalence studies are anonymised.
No routine screening can yet take place as there are no suitable validated screening tests for abnormal prion protein available. The Department, together with the United Kingdom Blood Services, continues to monitor, scientific research and development in this area.
http://www.publications.parliament.uk/pa/cm201314/cmhansrd/cm131112/text/131112w0004.htm#13111283000003
Monday, October 14, 2013
Researchers estimate one in 2,000 people in the UK carry variant CJD proteins
http://creutzfeldt-jakob-disease.blogspot.com/2013/10/researchers-estimate-one-in-2000-people.html
Tuesday, October 29, 2013
VARIANT CJD PRESENTS DIFFERENTLY IN OLDER PATIENTS
http://creutzfeldt-jakob-disease.blogspot.com/2013/10/variant-cjd-presents-differently-in.html
Wednesday, October 09, 2013
*** WHY THE UKBSEnvCJD ONLY THEORY IS SO POPULAR IN IT'S FALLACY, £41,078,281 in compensation REVISED
http://creutzfeldt-jakob-disease.blogspot.com/2013/10/why-ukbsenvcjd-only-theory-is-so.html
Thursday, October 10, 2013
CJD REPORT 1994 increased risk for consumption of veal and venison and lamb
http://creutzfeldt-jakob-disease.blogspot.com/2013/10/cjd-report-1994-increased-risk-for.html
CJD REPORT 1994 increased risk for consumption of veal and venison and lamb
http://creutzfeldt-jakob-disease.blogspot.com/2013/10/cjd-report-1994-increased-risk-for.html
Friday, August 16, 2013
*** Creutzfeldt-Jakob disease (CJD) biannual update August 2013 U.K. and Contaminated blood products induce a highly atypical prion disease devoid of PrPres in primates
http://creutzfeldt-jakob-disease.blogspot.com/2013/08/creutzfeldt-jakob-disease-cjd-biannual.html
WHAT about the sporadic CJD TSE proteins ?
WE now know that some cases of sporadic CJD are linked to atypical BSE and atypical Scrapie, so why are not MORE concerned about the sporadic CJD, and all it’s sub-types $$$
Creutzfeldt-Jakob Disease CJD cases rising North America updated report August 2013
*** Creutzfeldt-Jakob Disease CJD cases rising North America with Canada seeing an extreme increase of 48% between 2008 and 2010 ***
http://creutzfeldt-jakob-disease.blogspot.com/2013/08/creutzfeldt-jakob-disease-cjd-cases.html
Sunday, October 13, 2013
CJD TSE Prion Disease Cases in Texas by Year, 2003-2012
http://creutzfeldt-jakob-disease.blogspot.com/2013/10/cjd-tse-prion-disease-cases-in-texas-by.html
Monday, September 02, 2013
Lessons from the response to the threat of transfusion-transmitted vCJD in Ireland
http://vcjdtransfusion.blogspot.com/2013/09/lessons-from-response-to-threat-of.html
Saturday, November 2, 2013
Recommendation of the Swiss Expert Committee for Biosafety on the classification of activities using prion genes and prion protein January 2013
http://transmissiblespongiformencephalopathy.blogspot.com/2013/11/recommendation-of-swiss-expert.html
Recommendation of the Swiss Expert Committee for Biosafety on the classification of activities using prion genes and prion protein January 2013
http://transmissiblespongiformencephalopathy.blogspot.com/2013/11/recommendation-of-swiss-expert.html
Saturday, November 2, 2013
APHIS Finalizes Bovine Import Regulations in Line with International Animal Health Standards while enhancing the spread of BSE TSE prion mad cow type disease around the Globe
http://madcowusda.blogspot.com/2013/11/aphis-finalizes-bovine-import.html
I AGREE WITH MR. BULLARD, it’s all about trade and money, BSE TSE PRION aka mad cow type disease and sound science there from, was thrown out the window by the USDA et al that fateful day in December 23, 2003, when the USDA lost it’s ‘gold card’ of supposedly being BSE FREE, (that was and still is a sad joke though), that’s when mad cow junk science was adopted by the USDA...
see why below...kind regards, terry
Monday, November 4, 2013
*** R-CALF Bullard new BSE rule represents the abrogation of USDA’s responsibility to protect U.S. consumers and the U.S. cattle herd from the introduction of foreign animal disease
http://madcowusda.blogspot.com/2013/11/r-calf-bullard-new-bse-rule-represents.html
*** Saturday, November 2, 2013 ***
Exploring the risks of a putative transmission of BSE to new species
Wednesday, September 25, 2013
Presence of subclinical infection in gene-targeted human prion protein transgenic mice exposed to atypical BSE
http://bse-atypical.blogspot.com/2013/09/presence-of-subclinical-infection-in.html
I ask Professor Kong ; Thursday, December 04, 2008 3:37 PM
Subject: RE: re--Chronic Wating Disease (CWD) and Bovine Spongiform Encephalopathies (BSE): Public Health Risk Assessment ''IS the h-BSE more virulent than typical BSE as well, or the same as cBSE, or less virulent than cBSE? just curious.....'' Professor Kong reply ;
.....snip
''As to the H-BSE, we do not have sufficient data to say one way or another, but we have found that H-BSE can infect humans. I hope we could publish these data once the study is complete. Thanks for your interest.''
Best regards, Qingzhong Kong, PhD Associate Professor Department of Pathology Case Western Reserve University Cleveland, OH 44106 USA END...TSS
Thursday, December 04, 2008 2:37 PM
"we have found that H-BSE can infect humans."
personal communication with Professor Kong. ...TSS
BSE-H is also transmissible in our humanized Tg mice. The possibility of more than two atypical BSE strains will be discussed.
Supported by NINDS NS052319, NIA AG14359, and NIH AI 77774.
http://www.prion2009.com/sites/default/files/Prion2009_Book_of_Abstracts.pdf
please see below from PRION2013 ;
*** This study imply the possibility that the novel BSE prions with high virulence in cattle will be emerged during intraspecies transmission.
AD.56: The emergence of novel BSE prions by serial passages of H-type BSE in bovinized mice
Kentaro Masujin, Naoko Tabeta, Ritsuko Miwa, Kohtaro Miyazawa, Hiroyuki Okada, Shirou Mohri and Takashi Yokoyama National Institute of Animal Health; Tsukuba, Japan
H-type bovine spongiform encephalopathy (BSE) is an atypical form of BSE, and has been detected in several European countries, and North America. Transmission studies of H-type BSE led to the emergence of the classical BSE (C-BSE) phenotypes during passages in inbred wild type and bovinized PrP-overexpressing transgenic mice. In this study, we conducted serial passages of Canadian H-type BSE isolate in bovinized PrP-overexpressing transgenic mice (TgBoPrP). H-type BSE isolate was transmitted to TgBoPrP with incubation periods of 320 ± 12.2 d at primary passage. The incubation period of 2nd and 3rd passage were constant (~= 220 d), no clear differences were observed in their biological and biochemical properties. However, at the forth passage, 2 different BSE phenotypes were confirmed; one is shorter survival times (109 ± 4 d) and the other is longer survival times. TgBoPrP mice with longer incubation period showed the H-type phenotype of PrPsc profile and pathology. However, those of shorter incubation period were different phenotypes from previously existed BSE prions (C-BSE, L-type BSE, and H-type BSE).
*** This study imply the possibility that the novel BSE prions with high virulence in cattle will be emerged during intraspecies transmission.
http://www.prion2013.ca/tiny_uploads/forms/Scientific-Program.pdf
please see ;
Thursday, August 15, 2013
The emergence of novel BSE prions by serial passages of H-type BSE in bovinized mice
http://bse-atypical.blogspot.com/2013/08/the-emergence-of-novel-bse-prions-by.html
Sunday, September 1, 2013
*** Evaluation of the Zoonotic Potential of Transmissible Mink Encephalopathy
We previously described the biochemical similarities between PrPres derived from L-BSE infected macaque and cortical MM2 sporadic CJD: those observations suggest a link between these two uncommon prion phenotypes in a primate model (it is to note that such a link has not been observed in other models less relevant from the human situation as hamsters or transgenic mice overexpressing ovine PrP [28]). We speculate that a group of related animal prion strains (L-BSE, c-BSE and TME) would have a zoonotic potential and lead to prion diseases in humans with a type 2 PrPres molecular signature (and more specifically type 2B for vCJD)
snip...
Together with previous experiments performed in ovinized and bovinized transgenic mice and hamsters [8,9] indicating similarities between TME and L-BSE, the data support the hypothesis that L-BSE could be the origin of the TME outbreaks in North America and Europe during the mid-1900s.
http://transmissiblespongiformencephalopathy.blogspot.com/2013/09/evaluation-of-zoonotic-potential-of.html
Monday, October 10, 2011
EFSA Journal 2011 The European Response to BSE: A Success Story
snip...
EFSA and the European Centre for Disease Prevention and Control (ECDC) recently delivered a scientific opinion on any possible epidemiological or molecular association between TSEs in animals and humans (EFSA Panel on Biological Hazards (BIOHAZ) and ECDC, 2011). This opinion confirmed Classical BSE prions as the only TSE agents demonstrated to be zoonotic so far but the possibility that a small proportion of human cases so far classified as "sporadic" CJD are of zoonotic origin could not be excluded. Moreover, transmission experiments to non-human primates suggest that some TSE agents in addition to Classical BSE prions in cattle (namely L-type Atypical BSE, Classical BSE in sheep, transmissible mink encephalopathy (TME) and chronic wasting disease (CWD) agents) might have zoonotic potential.
snip...
http://www.efsa.europa.eu/en/efsajournal/pub/e991.htm?emt=1
see follow-up here about North America BSE Mad Cow TSE prion risk factors, and the ever emerging strains of Transmissible Spongiform Encephalopathy in many species here in the USA, including humans ;
http://transmissiblespongiformencephalopathy.blogspot.com/2011/10/efsa-journal-2011-european-response-to.html
Thursday, August 12, 2010
Seven main threats for the future linked to prions
First threat
The TSE road map defining the evolution of European policy for protection against prion diseases is based on a certain numbers of hypotheses some of which may turn out to be erroneous. In particular, a form of BSE (called atypical Bovine Spongiform Encephalopathy), recently identified by systematic testing in aged cattle without clinical signs, may be the origin of classical BSE and thus potentially constitute a reservoir, which may be impossible to eradicate if a sporadic origin is confirmed.
***Also, a link is suspected between atypical BSE and some apparently sporadic cases of Creutzfeldt-Jakob disease in humans. These atypical BSE cases constitute an unforeseen first threat that could sharply modify the European approach to prion diseases.
Second threat
snip...
http://www.neuroprion.org/en/np-neuroprion.html
http://transmissiblespongiformencephalopathy.blogspot.com/2011/05/variably-protease-sensitive-prionopathy.html
http://prionopathy.blogspot.com/2010/11/variably-protease-sensitive-prionopathy.html
Friday, October 25, 2013
UK FSA TSE BSE Board meeting agenda: 5 November 2013
http://transmissiblespongiformencephalopathy.blogspot.com/2013/10/uk-fsa-tse-bse-board-meeting-agenda-5.html
Wednesday, November 13, 2013
CJD House of Commons Tuesday 12 November 2013
http://creutzfeldt-jakob-disease.blogspot.com/2013/11/cjd-house-of-commons-tuesday-12.html
*** 1998 MY SUBMISSION TO THE BSE INQUIRY ENGLAND ***
Sender: "Patricia Cantos"
To: "Terry S Singeltary Sr. (E-mail)"
Subject: Your submission to the Inquiry
Date: Fri, 3 Jul 1998 10:10:05 +0100
3 July 1998 Mr Terry S Singeltary Sr. E-Mail: Flounder at wt.net Ref: E2979
Dear Mr Singeltary,
Thank you for your E-mail message of the 30th of June 1998 providing the Inquiry with your further comments. Thank you for offering to provide the Inquiry with any test results on the nutritional supplements your mother was taking before she died.
As requested I am sending you our general Information Pack and a copy of the Chairman's letter. Please contact me if your system cannot read the attachments. Regarding your question, the Inquiry is looking into many aspects of the scientific evidence on BSE and nvCJD. I would refer you to the transcripts of evidence we have already heard which are found on our internet site at http://www.bse.org.uk. Could you please provide the Inquiry with a copy of the press article you refer to in your e-mail? If not an approximate date for the article so that we can locate it? In the meantime, thank you for you comments. Please do not hesitate to contact me on 0171 261 8332 should you have any queries.
Yours sincerely Patricia Cantos Families Team Leader Attachments TSS
==============
My neighbors Mom also died from CJD. She had been taking a nutritional supplement which contained the following; vacuum dried bovine BRAIN, bone meal, bovine EYE, veal bone, bovine liver powder, bovine adrenal, vacuum dried bovine kidney, and vacuum dried porcine stomach. As I said, this woman taking these nutritional supplements, died from CJD. The particular batch of pills that was located, in which she was taking, was tested. From what I have heard, they came up negative, for the prion protein. But, in the same breath, they said their testing, may not have been strong enough to pick up the infectivity. Plus, she had been taking these type pills for years, so, could it have come from another batch?
http://www.bmj.com/cgi/eletters/319/7220/1312/b#5406
IPLEX, mad by standard process;
vacuum dried bovine BRAIN, bone meal, bovine EYE, veal Bone, bovine liver powder, bovine adrenal, vacuum dried bovine kidney, and vacuum dried porcine stomach.
also;
i will only list animal ingredients of the following Nutritional Supplements by only ONE company; Standard Process Co.
IPLEX; bovine EYE PMG Extract, veal bone PMG Extract, bovine liver powder, vaccuum dried porcine stomach, vacuum dried bovine adrenal, vacuum dried bovine kidney, bovine adrenal, vacuum dried BOVINE BRAIN, bone meal, vacuum dried veal bone.
A-FBetafood R vacuum dried bovine prostate, bovine liver powder, vacuum dried bovine kidney, bovine orchic glandular extract, bovine liver fat extract.
Arginex R bovine liver powder.
Adrenal, Desiccated TM Vacuum dried bovine adrenal.
Albaplex R bovine liver PMG Extract, vacuum dried bovine adrenal, bovine kidney PMF Extract, bovine thymus Cytosol Extract, bovine liver powder, bone meal, vacuum dried bovine kidney, veal bone meal.
Allerplex TM bovine lung PMF Extract, bovine adrenal PMF Extract, bovine liver fat extract (yakriton), bone meal, vacuum dried bovine kidney, vacuum dried veal bone.
Immuplex R Bovine liver PMG Extract, bovine liver powder, veal bone PMF Extract, bovine spleen PMF Extract, vacuum dried bovine and ovine spleen, bovine thymus PMF Extract, bovine thymus Cytosol Extract.
Vasculin R Bovine Heart PMG Extract, veal bone PMF Extract, bovine liver powder, vacuum dried porcine duodenum, bovine adrenal Cytosol Extract, vacuum dried bovine and ovine spleen.
Zypan R bovine pancreas Cytosol Extract, vacuum dried bovine and ovine spleen.
last i heard, they were getting sued;
Suit Filed Over Mad Cow Disclaimer
By Jason Hoppin The Recorder March 23, 2001
snip...see full text ;
http://creutzfeldt-jakob-disease.blogspot.com/2010/02/import-alert-17-04-bse-cjd-high-risk.html
snip...see full text ;
Sunday, November 10, 2013
LARGE CJD TSE PRION POTENTIAL CASE STUDY AMONG HUMANS WHO TAKE DEER ANTLER VELVET WILL BE ONGOING FOR YEARS IF NOT DECADES, but who's cares $
http://creutzfeldt-jakob-disease.blogspot.com/2013/11/large-cjd-tse-prion-potential-case.html
LARGE CJD TSE PRION POTENTIAL CASE STUDY AMONG HUMANS WHO TAKE DEER ANTLER VELVET WILL BE ONGOING FOR YEARS IF NOT DECADES, but who's cares $
http://creutzfeldt-jakob-disease.blogspot.com/2013/11/large-cjd-tse-prion-potential-case.html
Wednesday, March 20, 2013
GAO-13-244, Mar 18, 2013 Dietary Supplements FDA May Have Opportunities to Expand Its Use of Reported Health Problems to Oversee Product
From: Terry S. Singeltary Sr.
Sent: Tuesday, March 19, 2013 2:46 PM
To: gomezj@gao.gov Cc: siggerudk@gao.gov ; youngc1@gao.gov ; oighotline@gao.gov http://transmissiblespongiformencephalopathy.blogspot.com/2013/03/gao-13-244-mar-18-2013-dietary.html
GAO-13-244, Mar 18, 2013 Dietary Supplements FDA May Have Opportunities to Expand Its Use of Reported Health Problems to Oversee Product
From: Terry S. Singeltary Sr.
Sent: Tuesday, March 19, 2013 2:46 PM
To: gomezj@gao.gov Cc: siggerudk@gao.gov ; youngc1@gao.gov ; oighotline@gao.gov http://transmissiblespongiformencephalopathy.blogspot.com/2013/03/gao-13-244-mar-18-2013-dietary.html
NORDION (US), INC., AND BIOAXONE BIOSCIENCES, INC., Settles $90M Mad Cow TSE prion Contamination Suit Cethrin(R)
Case 0:12-cv-60739-RNS Document 1 Entered on FLSD Docket 04/26/2012 Page 1 of 15
http://creutzfeldt-jakob-disease.blogspot.com/2013/09/nordion-us-inc-and-bioaxone-biosciences.html
Sunday, June 9, 2013
TSEAC March 14, 2013: Transmissible Spongiform Encephalopathies Advisory Committee Meeting Webcast
http://tseac.blogspot.com/2013/06/tseac-march-14-2013-transmissible.html
TSEAC March 14, 2013: Transmissible Spongiform Encephalopathies Advisory Committee Meeting Webcast
http://tseac.blogspot.com/2013/06/tseac-march-14-2013-transmissible.html
BSE INQUIRY WHITEWASH
BSE INQUIRY DFAs
Sunday, May 18, 2008
BSE Inquiry DRAFT FACTUAL ACCOUNT DFA
BSE Inquiry DRAFT FACTUAL ACCOUNTS DFA's
BSE, CJD, and Baby foods (the great debate 1999 to 2005)
Sunday, May 18, 2008
MAD COW DISEASE BSE CJD CHILDREN
VACCINES
LAYPERSON
MOM DOD DECEMBER 14, 1997 CONFIRMED HEIDENHAIN VARIANT CREUTZFELDT JAKOB
DISEASE hvCJD...just made a promise to mom, never forget, never let them forget.
...TSS
From: noreply@parliament.uk
Sent: Tuesday, December 03, 2013 4:49 AM
Subject: Written submission to House of Commons Science and
Technology Committee inquiry
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Thank you for your written submission to the House of Commons Science and
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