Numero de focos de Encefalopatia Espongiforme Bovine en Espana 2009 - 1010
2009 = 18 cases BSE
http://www.eeb.es/pags/2009.htm
2010 to date = 4 cases of BSE
http://www.eeb.es/pags/espana.htm#2010
BSE SPAIN
Año 2000
http://www.eeb.es/pags/2000.htm
Año 2001
http://www.eeb.es/pags/2000.htm#2001
Año 2002
http://www.eeb.es/pags/2002.htm
Año 2003
http://www.eeb.es/pags/2003.htm
Año 2004
http://www.eeb.es/pags/2004.htm
Año 2005
http://www.eeb.es/pags/2005.htm
Año 2006
http://www.eeb.es/pags/2006.htm
Año 2007
http://www.eeb.es/pags/2007.htm
Año 2008
http://www.eeb.es/pags/2008.htm
Año 2009
http://www.eeb.es/pags/2009.htm
BSE SPAIN 2010 Situacion en Espana Total casos
http://www.eeb.es/pags/espana.htm#2010
Greetings,
PLEASE NOTE HIGH INCIDENT OF SPORADIC CJD AND BSE IN THE ALAVA, VIZCAYA, AND GUIPUZCOA AREAS ? another coincident, or BSE related. remember, BSE will propagate as nvCJD and or sporadic CJD in humanized transgenic mice, and please NOTE ALSO, the close proximity of BASQUE COUNTRY SPAIN TO ALAVA, VIZCAYA, AND GUIPUZCOA AREAS ? SO, you have a high rate of sporadic CJD cases in an area of BSE and Nor-98 atypical scrapie cases, another spontaneous coincidence, or a related event ?
NOTE THE SPORADIC CJD INCIDENT RATE AT > 2 CASES PER MILLION ;
SEE CJD UPDATE 2010
SEE PAGE 4 ;
Notificaciones* al RNEETH (1993-febrero 2010)
• Por año diagnóstico. Existe 1 caso más sin año diagnóstico
AÑO
CCAA 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 TOTAL
Andalucia 4 6 2 2 5 4 8 11 16 14 9 11 16 15 13 19 11 1 167
Aragon 0 0 1 0 5 4 1 3 4 0 2 0 5 2 2 5 4 1 39
Asturias 2 0 2 0 1 2 3 2 2 0 5 2 1 0 0 0 0 0 22
Baleares 1 2 0 1 1 0 2 0 1 1 1 3 1 0 0 1 4 0 19
Canarias 0 0 0 0 4 4 4 2 2 2 2 2 2 3 3 1 3 0 34
Cantabria 1 2 0 0 2 4 3 3 0 2 0 0 1 0 0 2 0 0 20
Castilla la Mancha 0 1 1 2 2 1 2 2 1 2 0 2 5 3 5 6 7 0 42
Castilla-Leon 2 1 6 2 7 4 4 6 8 5 6 6 7 7 7 12 5 0 95
Cataluna 8 6 3 6 6 15 16 9 13 11 7 19 15 16 13 14 7 0 184
Valencia 1 3 3 7 5 12 11 10 12 13 17 10 8 8 19 16 9 2 166
Extremadura 0 0 0 1 1 2 2 0 0 3 1 0 2 7 5 3 1 0 28
Galicia 1 1 3 0 0 11 3 5 8 7 1 7 6 5 3 2 0 0 63
Madrid 4 4 5 7 5 7 9 10 16 7 12 8 13 16 8 8 13 0 152
Murcia 1 0 0 0 1 0 1 0 2 3 2 2 3 1 6 2 3 0 27
Navarra 1 0 0 2 1 0 2 2 1 0 0 0 4 2 0 0 0 0 15
Pais Vasco 2 3 1 6 4 8 5 8 8 9 7 6 11 10 11 8 4 1 112
La Rioja 2 0 0 0 1 1 0 0 1 0 1 0 1 0 1 0 0 0 8
TOTAL 30 29 27 36 51 79 76 73 95 79 73 78 101 95 96 99 71 5 1193
• Por año diagnóstico. Existe 1 caso más sin año diagnóstico
REGISTRO ESPAÑOL DE EETH
1993-febrero 2010
ECJ = 957
vECJ = 5
IFL = 44
GSS = 2
Esporadico = 905
Familiar = 46
Yatrogenico = 6
* Existen 2 casos mas con diagnóstico pendiente de clasificación
ALSO, ON PAGE 14, NOTE THE HIGH INCIDENCE IN THIS SAME AREA ;
Número de casos de Insomnio Familiar Letal por CA. 1993-febrero 2010
HIGH INCIENCE RATE AT 18 CASES
please see full text ;
REGISTRO NACIONAL DE ENCEFALOPATÍAS ESPONGIFORMES TRANSMISIBLES HUMANAS C.N.E y Servicios de Vigilancia Epidemiológica de CCAA (Situación a 15 de febrero de 2010)
http://www.isciii.es/htdocs/pdf/DatosRegistroCreutzfeldJacob2.pdf
The EMBO Journal (2002) 21, 6358 - 6366 doi:10.1093/emboj/cdf653
BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein
Emmanuel A. Asante1, Jacqueline M. Linehan1, Melanie Desbruslais1, Susan Joiner1, Ian Gowland1, Andrew L. Wood1, Julie Welch1, Andrew F. Hill1, Sarah E. Lloyd1, Jonathan D.F. Wadsworth1 and John Collinge1
1.MRC Prion Unit and Department of Neurodegenerative Disease, Institute of Neurology, University College, Queen Square, London WC1N 3BG, UK Correspondence to:
John Collinge, E-mail: j.collinge@prion.ucl.ac.uk
Received 1 August 2002; Accepted 17 October 2002; Revised 24 September 2002
--------------------------------------------------------------------------------
Abstract
Variant Creutzfeldt–Jakob disease (vCJD) has been recognized to date only in individuals homozygous for methionine at PRNP codon 129. Here we show that transgenic mice expressing human PrP methionine 129, inoculated with either bovine spongiform encephalopathy (BSE) or variant CJD prions, may develop the neuropathological and molecular phenotype of vCJD, consistent with these diseases being caused by the same prion strain. Surprisingly, however, BSE transmission to these transgenic mice, in addition to producing a vCJD-like phenotype, can also result in a distinct molecular phenotype that is indistinguishable from that of sporadic CJD with PrPSc type 2. These data suggest that more than one BSE-derived prion strain might infect humans; it is therefore possible that some patients with a phenotype consistent with sporadic CJD may have a disease arising from BSE exposure.
Keywords:BSE, Creutzfeldt–Jakob disease, prion, transgenic
http://www.nature.com/emboj/journal/v21/n23/abs/7594869a.html
Monday, May 19, 2008
SPORADIC CJD IN FARMERS, FARMERS WIVES, FROM FARMS WITH BSE HERD AND ABATTOIRS
http://bseinquiry.blogspot.com/
Sunday, August 10, 2008
A New Prionopathy OR more of the same old BSe and sporadic CJD
http://creutzfeldt-jakob-disease.blogspot.com/2008/08/new-prionopathy-or-more-of-same-old-bse.html
Atypical/Nor98 scrapie in the Basque Country: a case report of eight outbreaks
BMC Veterinary Research 2010, 6:17 doi:10.1186/1746-6148-6-17
http://www.biomedcentral.com/content/pdf/1746-6148-6-17.pdf
Sunday, March 28, 2010
Atypical/Nor98 scrapie in the Basque Country: a case report of eight outbreaks
http://nor-98.blogspot.com/2010/03/atypicalnor98-scrapie-in-basque-country.html
Wednesday, March 3, 2010
NOR-98 ATYPICAL SCRAPIE USA 4 CASES DETECTED JANUARY 2010
Greetings,
Unusual event if you consider the officials hypothisis that Nor-98 atypical scrapie is a spontaneous event. seems there was a great deal of spontaneous mutations for this time period ;-)...TSS
http://nor-98.blogspot.com/2010/03/nor-98-atypical-scrapie-usa-4-cases.html
Thursday, March 11, 2010
CANADA TYPICAL AND ATYPICAL SCRAPIE REPORT TO MARCH 2010
http://nor-98.blogspot.com/2010/03/canada-typical-and-atypical-scrapie.html
Monday, November 30, 2009
USDA AND OIE COLLABORATE TO EXCLUDE ATYPICAL SCRAPIE NOR-98 ANIMAL HEALTH CODE
http://nor-98.blogspot.com/2009/11/usda-and-oie-collaborate-to-exclude.html
Monday, December 14, 2009
Similarities between Forms of Sheep Scrapie and Creutzfeldt-Jakob Disease Are Encoded by Distinct Prion Types
hmmm, this is getting interesting now...
Sporadic CJD type 1 and atypical/ Nor98 scrapie are characterized by fine (reticular) deposits,
see also ;
All of the Heidenhain variants were of the methionine/ methionine type 1 molecular subtype.
http://cjdusa.blogspot.com/2009/09/co-existence-of-scrapie-prion-protein.html
see full text ;
Monday, December 14, 2009
Similarities between Forms of Sheep Scrapie and Creutzfeldt-Jakob Disease Are Encoded by Distinct Prion Types
http://nor-98.blogspot.com/2009/12/similarities-between-forms-of-sheep.html
TSS